Wnt/β‑catenin pathway activation and silencing of the APC gene in ...

The present study suggested that the increase in Wnt activity in certain cervical cancer‐derived cells may be associated with an alteration in the methylation ...

Wnt/β-catenin pathway activation and silencing of the APC gene in ...

The present study suggested that the increase in Wnt activity in certain cervical cancer-derived cells may be associated with an alteration in the methylation ...

Wnt/β-catenin pathway activation and silencing of - ProQuest

Wnt/β-catenin pathway activation and silencing of the APC gene in HPV-positive human cervical cancer-derived cells. Ayala-Calvillo, Erick; Mojica-Vázquez ...

Wnt/β‑catenin pathway activation and silencing of the APC gene in ...

Wnt/β‑catenin pathway activation and silencing of the APC gene in HPV‑positive human cervical cancer‑derived cells · Erick Ayala‑Calvillo · Luis Humberto Mojica‑ ...

[PDF] Wnt/β-catenin pathway activation and silencing of the APC ...

It was hypothesized that APC alteration may lead to β-catenin deregulation and the abnormal expression of direct targets of the Wnt pathway in HPV-infected ...

Wnt/βcatenin pathway activation and silencing of the APC gen...

Mutations or epigenetic inactivation of the tumor suppressor adenomatous polyposis coli (APC), the two acting as prominent oncogenic mechanisms in a number of ...

Wnt/beta-catenin pathway: modulating anticancer immune response

β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling.

Wnt/β-catenin signalling: function, biological mechanisms ... - Nature

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.

The regulation of β-catenin activity and function in cancer - Oncotarget

TRIM33 is another E3 ubiquitin ligase targeting nuclear active β-catenin and acts regardless of Wnt signaling activation [43]. Phosphorylation ...

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

APC has also been shown to promote β-catenin nuclear export and to act as a chromatin-associated suppressor for β-catenin target genes, thus ...

mutant colorectal cancer is dependent on Wnt/β-catenin signaling

Results · Sustained Wnt/β-Catenin Pathway Activation Is Required for Maintenance of Colorectal Tumors Harboring APC Mutations. · In Vivo ...

β-Catenin signaling in hepatocellular carcinoma - JCI

Activated Wnt/β-catenin synergizes with multiple signaling cascades to drive HCC formation, and it functions through its downstream effectors.

APC/β-catenin-rich complexes at membrane protrusions regulate ...

While loss of the APC tumor suppressor has been demonstrated in numerous studies to facilitate tumor initiation by activating Wnt signaling and ...

Wnt Signaling Pathway - an overview | ScienceDirect Topics

The canonical Wnt signaling pathway is the β-catenin-dependent activation of Wnt signal. ... mutation of APC or β-catenin was not observed.4 However, reduced ...

The role of APC in WNT pathway activation in serrated neoplasia

WNT pathway activation may also occur, however, to what extent this is owing to APC mutation is unknown. We examined aberrant nuclear β-catenin ...

Wnt/β‑catenin pathway activation and silencing of the APC gene in ...

Mutations or epigenetic inactivation of the tumor suppressor adenomatous polyposis coli (APC), the two acting as prominent oncogenic mechanisms in a number of ...

Wnt/β-catenin pathway activation and silencing of the APC gene in ...

Wnt/β-catenin pathway activation and silencing of the APC gene in HPV-positive human cervical cancer-derived cells.

No evidence for involvement of β-catenin and APC in urothelial ...

The wnt pathway plays an important role in embryonal patterning and cell fate determination, involving stabilization of nuclear and cytoplasmic ...

Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in ...

The non-canonical Wnt pathway is independent of β-catenin. Wnt activation leads to complex formation between ROR and Frizzled which allows activation of ...

β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic ...

In addition to the well-characterized effects of canonical Wnt pathway activation, new mechanisms by which β-catenin contributes to tumor progression are ...