X|Chromosome Inactivation and Escape from X Inactivation in Mouse

X-Chromosome Inactivation and Escape from X Inactivation in Mouse

X chromosome inactivation silences one X chromosome in female mammals. However, this silencing is incomplete, and some genes escape X inactivation.

Escape from X inactivation in mice and humans - Genome Biology

A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females.

X Inactivation and Escape: Epigenetic and Structural Features

X inactivation represents a complex multi-layer epigenetic mechanism that profoundly modifies chromatin composition and structure of one X chromosome in ...

Escape from X Inactivation Varies in Mouse Tissues | PLOS Genetics

Overall, few genes (3–7%) escape XCI in any of the mouse tissues examined, suggesting stringent silencing and escape controls.

Human genes escaping X-inactivation revealed by single cell ...

While most genes from the inactivated X-chromosome are silenced, 15–25% are known to escape X-inactivation (termed escapees).

Landscape of X chromosome inactivation across human tissues

While tissue-specific escape is common in mouse, limited evidence exists for such a pattern in human tissues other than for neurons. In our data ...

Escape From X-Chromosome Inactivation: An Evolutionary ...

Mouse models that can dissect the role of the sex chromosomes distinct from sex of the organism reveal an important contribution for escape genes to multiple ...

Refining the genomic determinants underlying escape from X ...

X-chromosome inactivation (XCI) epigenetically silences one X chromosome in every cell in female mammals. Although the majority of X-linked ...

Global survey of escape from X inactivation by RNA-sequencing in ...

Thirteen of 393 (3.3%) mouse genes had significant expression from the inactive. X, including eight novel escape genes. We estimate that mice have significantly ...

UTX Gene Escapes X Inactivation in Mice and Humans | Oxford

We assayed for Utx expression from the inactive X chromosome (Xi) in mice and found that Utx escapes X chromosome inactivation.

Variable escape from X‐chromosome inactivation: Identifying factors ...

In mice, a smaller percentage (perhaps 3%) of genes escape from XCI, consistent with the viability and limited phenotypic consequences for ...

Dynamic changes in paternal X-chromosome activity during ... - PNAS

In mice, X inactivation is initially imprinted, with inactivation of the paternal X (Xp) chromosome occurring during preimplantation development.

A cross-species comparison of X-chromosome inactivation in Eutheria

In Eutheria, X inactivation is initiated by the large noncoding RNA Xist; however, it is unknown how this RNA results in silencing of the chromosome or why, at ...

X-chromosome inactivation: a historic topic that's still hot

In mouse, the whole embryo initiates imprinted paternal X-chromosome inactivation (XCI) soon after zygotic genome activation. The inner cell ...

Genes that escape from X‐chromosome inactivation: Potential ...

Not all X-linked genes are completely inactivated, however, with 12% of genes escaping X chromosome inactivation and another 15% of genes ...

Heterogeneous gene expression from the inactive X chromosome

Previously, three different expression patterns have been recognized for X-linked genes: those subject to X inactivation, those escaping inactivation, and a ...

X-Chromosome Inactivation and Escape from X Inactivation in Mouse

However, this silencing is incomplete, and some genes escape X inactivation. We describe methods to determine the chromosome-wide X inactivation status of genes ...

Skewed X-inactivation is common in the general female population

In humans, nearly 15% of X-linked genes are thought to escape inactivation and are expressed from both active and inactive X-chromosomes [14].

X Chromosome Inactivation - an overview | ScienceDirect Topics

X-chromosome inactivation is the developmentally regulated process by which one of the two X-chromosomes in female mammals is silenced early in development to ...

Escape from X inactivation in human and mouse: Trends in Genetics

Genes that escape X inactivation have been recently found in human and in mouse. Although many of these genes have homologues on the Y chromosome.