Zeb1|induced metabolic reprogramming of glycolysis is essential for ...

Zeb1-induced metabolic reprogramming of glycolysis is essential for ...

These findings identify a Zeb1-dependent mechanism as a driver of breast cancer progression that acts by stimulating tumor–macrophage interplay.

Zeb1-induced metabolic reprogramming of glycolysis is essential for ...

These findings identify a Zeb1-dependent mechanism as a driver of breast cancer progression that acts by stimulating tumor-macrophage interplay.

[PDF] Zeb1-induced metabolic reprogramming of glycolysis is ...

Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer · Huimin Jiang, H. Wei, +9 authors. Shuang Yang ...

(PDF) Zeb1-induced metabolic reprogramming of glycolysis is ...

1C), immunoblotting (Fig. ... tumor cells compared to PyMT cells. ... identiﬁed Zeb1 as a key regulator of glycolytic gene expression. ... glycolytic ﬂux, and ...

Metabolic Reprogramming in Cancer Cells: Emerging Molecular ...

Among the most important metabolic changes produced by HIF-1α are increased glucose uptake, glycolysis, and decreased glucose oxidation through ...

Metabolic reprogramming from glycolysis to fatty acid uptake and ...

Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic reprograming during therapeutic resistance ...

Metabolic reprogramming in cancer: Mechanisms and therapeutics

It plays an important role in tumorigenesis by regulating cell metabolism and inducing glycolysis, PPP, pyrimidine biosynthesis, and redox ...

Metabolic Reprogramming Fuels Cell Growth and Proliferation

This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a ...

Metabolic reprogramming: the emerging concept and associated ...

Remarkably, cancer-associated fibroblasts in tumor stroma tend to activate both glycolysis and autophagy in contrast to neighboring cancer cells ...

Natural products targeting glycolysis in cancer - Frontiers

Metabolic reprogramming is a central hallmark of cancer and is critical for tumorigenesis and tumor progression (Liu D. et al., 2021). Natural ...

Metabolic Reprogramming Is Required for Antibody Production That ...

Similar to the reduced glycolysis of anergic (23) or memory T cells (22), B cell activation can fail to induce glycolysis if FcγRIIB is coligated (9). Tolerance ...

mTORC1-Dependent Metabolic Reprogramming Underlies Escape ...

Combined inhibition of glycolysis and mTORC1 signaling disrupted metabolic reprogramming in tumor cells and inhibited their growth in vitro and in vivo. These ...

The cancer metabolic reprogramming and immune response

Glycolysis plays an important role in the activation of DCs; however, DC mainly uses oxidative phosphorylation for energy metabolism in the ...

Metabolic reprogramming in triple-negative breast cancer

The metabolic rewiring of glycolysis due to dysregulated signaling can, in turn, promote oncogenic pathways through altered metabolites or ...

Metabolic Reprogramming in Thyroid Cancer

Glycolysis is a critical metabolic pathway that provides cancer cells with energy and building blocks for biosynthesis. Cancer cells upregulate ...

Metabolic reprogramming sustains cancer cell survival following ...

AMPK-Nrf2 signaling is crucial in metabolic reprogramming during cancer progression. •. Cancer metabolism does not preeminently depend on glycolysis. •.

Relationship Between Metabolic Reprogramming and Mitochondrial ...

critical role in the regulation of glycolysis under hypoxic conditions (44). c ... essential for OXPHOS in causing generation of ROS during oxygen contact.

Interplay between metabolic reprogramming and post-translational ...

mTOR activates HIF-1α and Myc to enhance glycolysis, glutaminolysis, and PPP (Figure 1) (5). The pathway plays a crucial role in regulating the expression and ...

Insights into Metabolic Reprogramming in Tumor Evolution ... - MDPI

... induction, which are critical for tumor progression. ... This reprogramming facilitates an enhanced reliance on glycolysis, providing a quick source of energy ...

Glycolysis in Cancer Therapy and Tumor Metabolism

In normal cells under ideal conditions, glucose enters the cell via glucose transporters (GLUT). Through the action of key glycolytic enzymes such as ...