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- Surrogate threshold effect🔍
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- an alternative measure for meta‐analytic surrogate endpoint validation🔍
- An Alternative Measure for Meta|analytic Surrogate Endpoint ...🔍
- An alternative measure for meta|analytic surrogate endpoint validation🔍
- An alternative trial|level measure for evaluating failure|time ...🔍
- Alternative methods to evaluate trial level surrogacy🔍
an alternative measure for meta‐analytic surrogate endpoint ...
an alternative measure for meta-analytic surrogate endpoint validation
In many therapeutic areas, the identification and validation of surrogate endpoints is of prime interest to reduce the duration and/or size of clinical ...
Surrogate threshold effect: an alternative measure for meta‐analytic ...
In many therapeutic areas, the identification and validation of surrogate endpoints is of prime interest to reduce the duration and/or size ...
18 An Alternative Measure for Meta-analytic Surrogate Endpoint ...
When considering the meta-analytic approach to the validation of surrogate endpoints (Chapter 7), Gail et al. (2000) noted that, unless the trial-level.
an alternative measure for meta‐analytic surrogate endpoint validation
A new concept is introduced, the so‐called surrogate threshold effect (STE), defined as the minimum treatment effect on the surrogate necessary to predict a ...
An Alternative Measure for Meta-analytic Surrogate Endpoint ...
'An Alternative Measure for Meta-analytic Surrogate Endpoint Validation' published in 'The Evaluation of Surrogate Endpoints'
An alternative measure for meta-analytic surrogate endpoint validation
Overall survival and progression-free survival curves for the meta-analysis of advanced ovarian cancer. Surrogate threshold effect 175.
An alternative measure for meta-analytic surrogate endpoint validation
... Surrogate threshold effect (STE) is defined as the minimum treatment effect on the surrogate endpoint necessary to predict a nonzero ...
An alternative trial-level measure for evaluating failure-time ...
To validate a failure-time surrogate for an established failure-time clinical endpoint such as overall survival, the meta-analytic approach is commonly used ...
an alternative measure for meta‐analytic surrogate endpoint validation
Surrogate threshold effect: an alternative measure for meta‐analytic surrogate endpoint validation (English) · How to get this title? · Export, share and cite.
An Alternative Measure for Meta-analytic Surrogate Endpoint ...
The surrogate threshold effect (STE) on PFS was calculated in all trials and subgroups. The STE is derived from a vertical line that transects the upper 95% ...
Alternative methods to evaluate trial level surrogacy - PubMed
... surrogate endpoints in randomized clinical trials. Later, Buyse et al. [5] proposed a meta-analytic ... surrogacy measure, which do not pre-specify the type ...
The meta-analytic framework for the evaluation of surrogate ...
... substitute for a clinical endpoint ... Burzykowski et al. Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation ...
[PDF] The validation of surrogate endpoints in meta-analyses of ...
Surrogate threshold effect: an alternative measure for meta‐analytic surrogate endpoint validation · T. BurzykowskiM. Buyse. Medicine. Pharmaceutical statistics.
The validation of surrogate endpoints in meta-analyses of ...
The two measures of association, one at the individual level, the other at the trial level, are proposed as an alternative way to assess the usefulness of a ...
Correlation between surrogate endpoints and overall survival in ...
& Buyse, M. Surrogate threshold effect: An alternative measure for meta-analytic surrogate endpoint validation. Pharm. Stat. 5, 173–186. https ...
The Strength of Association Between Surrogate End Points and ...
Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation. Pharm Stat. 2006;5(3):173-186.PubMed ...
Surrogate threshold effect: an alternative measure for meta-analytic ...
In many therapeutic areas, the identification and validation of surrogate endpoints is of prime interest to reduce the duration and/or size of clinical trials.
Systematic Review and Recommendation for Reporting of Surrogate ...
... clinical endpoints through meta-analytic ... M. Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.
Frequently asked questions on surrogate endpoints in oncology ...
These alternative endpoints are called surrogate measures. 1 ... clinical endpoint across multiple trials in a meta-analysis (Figure).
Surrogate endpoints for overall survival in randomized clinical trials ...
... an alternative measure of surrogacy. For the ... A systematic review and recommendation for reporting of surrogate endpoint evaluation using meta-analyses.