and age|specific differences revealed by mouse sarcopenia models

Mouse sarcopenia model reveals sex- and age-specific differences ...

Our study was to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition to investigate the underlying molecular mechanisms.

and age-specific differences revealed by mouse sarcopenia models

Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition.

Mouse sarcopenia model reveals sex- and age-specific differences ...

Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics

and age-specific differences revealed by mouse sarcopenia models

In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant ...

Mouse models of sarcopenia: classification and evaluation - PMC

The results showed that natural ageing of 25‐month‐old C57BL/6J mice was a reasonable model for the study of sarcopenia (defined as low muscle mass, strength, ...

Mouse sarcopenia model reveals sex- and age-specific differences ...

The results highlight the different trajectories of age-related declines in muscle mass and function, providing insights into sex-dependent molecular ...

Molecular and phenotypic analysis of rodent models reveals ...

This is where model organisms such as mice and rats, which exhibit morphological changes consistent with human sarcopenia after just 22–24 ...

Mouse models of accelerated aging in musculoskeletal research for ...

Mouse models of sarcopenia often involve genetically modified mice, age-induced muscle wasting, or disuse-induced muscle atrophy models (Rydell-Tormanen and ...

More age-related genes were identified in rat skeletal muscles compared with mice; this was consistent with the finding that rat muscles undergo ...

Translatability of mouse muscle-aging for humans: the role of sex

Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, ...

Panorama Public/2024/MacCoss - Mouse Skeletal Muscle Sarcopenia

Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics. J Clin Invest. 2024 Jun 11;134 ...

Sarcopenia phenotype and impaired muscle function in male mice ...

After middle age, with the control mice, the male fmARKO mice showed much less muscle function, accompanied by lower hindlimb muscle mass; this ...

Murine models of atrophy, cachexia, and sarcopenia in skeletal ...

Identifying animal models that reflect sarcopenia or its component pathways will enable researchers to better understand those pathways that contribute to age- ...

Experimental Models of Sarcopenia: Bridging Molecular Mechanism ...

It has been reported that SAMP6 mice at 60 weeks of age showed a decrease in the size of tibialis anterior muscle fibers [156]. SAMP10 mice showed aging-induced ...

Animal models of sarcopenia - Aging Cell - Wiley Online Library

The exact molecular mechanisms responsible for this pathology remain unknown. The use of model organisms, such as mice, rats, flies, and worms, ...

Caloric Restriction Combined with Immobilization as Translational ...

The proportion of slow myofibers increased with aging in mice (+5%, p<0.05), and this was not recapitulated by the CR and/or immobilization models. The diameter ...

Deficiency of skeletal muscle Agrin contributes to the pathogenesis ...

cKO mouse weights were not significantly reduced compared to those of Agrin f/f mice (control) at 1 and 3 months of age, but they were ...

Craig A. Goodman on X: "Mouse sarcopenia model reveals sex- and ...

Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics https://t.co/YQc4To0JyR.

Different phases of aging in mouse old skeletal muscle

They recognized malnutrition in females and higher serum myostatin in males as different risk factors for sex-specific difference of muscle ...

Sarcopenia and Aging: Skeletal Muscle Fiber Type Composition of ...

muscle and age group of mice. Future studies should include a larger sample ... minimize confounding effects of physiological differences between female and male.