and sex|specific colorectal cancer susceptibility genes with ...

and sex-specific colorectal cancer susceptibility genes with ...

We identified 35 genes with robust evidence for a potential causal role in CRC, including ten genes not previously identified by TWAS.

Sex and gender perspectives in colorectal cancer - PMC

As such, stronger associations between obesity and increased risk of overall CRC have been found in men, compared with women. Patterns also differ: weight gain ...

Identification of Susceptibility Loci and Genes for Colorectal Cancer ...

We identified 4 loci associated with CRC risk; P values for the most significant variant in each locus ranged from 3.92×10−8 to 1.24×10−12: 6p21.1 (rs4711689), ...

Genetics of Colorectal Cancer (PDQ®) - NCI

The important genes involved in these chromosome losses are APC (5q), DCC/MADH2/MADH4 (18q), and TP53 (17p).[64,66] These chromosomal losses are ...

Sex differences in colonic gene expression and fecal microbiota ...

Colorectal cancer, the third most common cancer in the world, is linked to several genetic and environmental factors. Epidemiological studies ...

Cancer Susceptibility Gene Mutations in Individuals With Colorectal ...

Beyond the classic hereditary CRC syndromes, mutations in other high-penetrance genes (BRCA1/2, PALB2, CDKN2A, and TP53) were identified in a ...

Sex hormones and genetic variants in hormone metabolic pathways ...

The different incidence of colorectal cancer between the sexes suggests that sex hormones may be involved in the susceptibility to colorectal cancer. The ...

Genetic predisposition to colorectal cancer: syndromes, genes ...

The most frequently mutated non-CRC hereditary genes identified in CRC patients are BRCA1 and BRCA2 (0.7–1.3% of CRC patients, regardless of ...

Prevalence and Penetrance of Major Genes and Polygenes for ...

Jenkins and colleagues estimated that 1 in 588 of the population carry major gene mutations associated with a recessively inherited risk, and these mutations ...

Identification of specific susceptibility loci for the early-onset ...

The incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising rapidly, whereas the EOCRC genetic ...

Hereditary Colon Cancer: Guide for Health Pros

Of all colon cancer cases, only about 5 to 10 percent are hereditary, linked to gene mutations inherited from one's mother or father. Multiple genes are ...

Genome-wide association study of colorectal cancer identifies six ...

The narrow-sense heritability estimates based on twin and family studies of CRC range from 12 to 35% (refs 2, 3). Although several genome-wide ...

Colorectal Cancer Risk Factors

Lynch syndrome is the most common hereditary colorectal cancer syndrome. It accounts for about 2% to 4% of all colorectal cancers. In most cases ...

A Model to Determine Colorectal Cancer Risk Using Common ...

We calculated the risk score for each tumor site based on the site-specific model and took the weighted average of the risk scores with weights equal to ...

Update on genetic predisposition to colorectal cancer and polyposis

This genetic predisposition to CRC has been classically associated with germline mutations or epimutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, ...

Epidemiology and risk factors for colorectal cancer - UpToDate

Hereditary CRC syndromes — Several specific genetic disorders, most of which are inherited in an autosomal-dominant fashion, are associated with ...

What you should know about genetics, colorectal cancer

This means that if you have a genetic predisposition for colorectal cancer, your children have a 50% chance of inheriting the genetic mutation ...

Causes of Colorectal Cancer | Is Colon Cancer Hereditary?

A mutation in one of the DNA repair genes like MLH1, MSH2, MSH6, PMS2, and EPCAM can allow DNA errors to go unfixed. These errors will sometimes ...

Genetic Predisposition to Colorectal Cancer: How Many and Which ...

Lynch syndrome and familial adenomatous polyposis are the best-known genetic diseases associated with hereditary colorectal cancer. However, some other genetic ...

Sexual Dimorphism in Colon Cancer - Frontiers

The available data suggest that men with Klinefelter syndrome have decreased risk for CRC (39), whereas Turner syndrome women have an increased risk comparing ...