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high interstitial fluid


High interstitial fluid pressure - an obstacle in cancer therapy

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in ...

High interstitial fluid pressure — an obstacle in cancer therapy - Nature

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in ...

Interstitial fluid pressure as an emerging biomarker in solid tumors

The importance of elevated IFP in limiting drug penetration is specifically important in the delivery of nanoparticles or drugs and compounds with a high ...

High Interstitial Fluid Pressure Is Associated with Low Tumour ...

Dense vascularisation was only present at the margins of the tumours. The existing blood vessels were irregular and were denoted as immature ( ...

Interstitial Fluid - an overview | ScienceDirect Topics

This technique requires tissue slices, thus cannot be performed in vivo, however, has high sensitivity and resolution. More recently Aspelund et al. measured ...

High interstitial fluid pressure promotes tumor cell proliferation and ...

The results revealed that the increased IFP resulted in a marked increase in cancer cell proliferation, survival and invasion in vitro.

Interstitial fluid pressure, vascularity and metastasis in ectopic ...

High tumour interstitial fluid pressure (IFP) has been adversely linked to poor drug uptake in patients, and to treatment response following radiotherapy in ...

High Interstitial Fluid Pressure Is Associated with Tumor-Line ... - PLOS

Interstitial fluid pressure (IFP) is highly elevated in many solid tumors. High IFP has been associated with low radiocurability and high metastatic frequency ...

The peptide AF-16 decreases high interstitial fluid pressure in solid ...

The full sequence of the peptide AF-16 is: H-Val-Ser-His-Ser-Lys-Thr-Arg-Ser-Asn-Pro-Glu-Asn-Asn-Val-Gly-Leu-OH, and the molecular weight is 1738.89 D.

Interstitial fluid pressure regulates collective invasion in engineered ...

High IFP, a characteristic of most solid tumors, has been shown to influence the migratory behavior of cancer cells in a variety of 3D culture models. However, ...

High interstitial fluid pressure — an obstacle in cancer therapy

Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

Interstitial Fluid Pressure and Associated Lymph Node Metastasis ...

Introduction. Malignant solid tumors generally have a higher interstitial fluid pressure (IFP) than normal tissues (1–3). Tumor tissues develop ...

Tumor Interstitial Fluid as Modulator of Cancer Inflammation ...

For almost 30 years TIF remained a neglected entity until it was demonstrated that TIF, and in particular its high pressure, constitutes an important obstacle ...

Tumor Interstitial Fluid Formation, Characterization, and ... - Frontiers

Potential biomarkers will appear locally in high concentrations in tumors and may eventually be found diluted in the plasma. Access to TIF that reliably ...

High interstitial fluid pressure (IFP) and hypoxia as biomarkers of ...

In patients with both high IFP and hypoxia a similar benefit of cisplatin was seen. Conclusions: Patients with high IFP and hypoxic tumours may ...

Interstitial fluid: the overlooked component of the tumor ...

Potential biomarkers will appear locally at high concentrations in the tissue of interest and will eventually appear in the plasma, where they ...

Longitudinal Monitoring of Simulated Interstitial Fluid Pressure for ...

High vessel permeability, poor perfusion, low lymphatic drainage, and dense abundant stroma elevate interstitial fluid pressures (IFP) in pancreatic ductal ...

Interstitial Fluid Pressure in Normal and Inflamed Pulp - Sage Journals

It seems physiologically beneficial, therefore, for the pulp to have a high tissue pressure, which promptly increases when blood flow increases due to its low ...

High interstitial fluid pressure — an obstacle in cancer therapy

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in ...

Interstitial fluid homeostasis and pressure: news from the black box

They investigated the relationship between interstitial fluid composition and interstitial fluid ... Tissue components with high GAG density therefore could have ...