neurodegenerative disease targets with small molecules

Small molecules to perform big roles: The search for Parkinson's ...

The motor symptoms described in PD are triggered by the neurodegeneration of dopaminergic neurons, partly due to an accumulation of intraneuronal abnormal alpha ...

Drugging "undruggable" neurodegenerative disease targets with ...

Drugging "undruggable" neurodegenerative disease targets with small molecules.

Small Molecules for neurodegenerative disease - Patsnap Synapse

Unlike traditional drug targets that have enzymatic activity and binding sites for small molecules to modulate their functions, pathological ...

Drugging "undruggable" neurodegenerative disease targets with ...

Drugging "undruggable" neurodegenerative disease targets with small molecules ... Abstract. As our population continues to age, neurodegenerative diseases are ...

Small Molecules for Neurodegeneration Applications - EMD Millipore

Aβ (β-amyloid peptide) is a major component of neuritic plaques and cerebrovascular amyloid deposits in the brains of patients with Alzheimer's disease (AD). A ...

neurodegenerative disease targets with small molecules - SciEngine

Here we discuss recent progress and envision future directions for small molecule drug discovery strategies to tackle ''undruggable” neurodegenerative disease ...

Small molecules to target tau amyloid aggregation

Protein aggregation has been linked with many neurodegenerative diseases, such as Alzheimer's disease (AD) or Parkinson's disease. AD belongs to a group of ...

Targeting RNA structures with small molecules - Nature

Promising therapeutic strategies to target RNA include antisense oligonucleotides (ASOs), CRISPR gene editing and small molecules that recognize RNA structures.

Small-molecule drugs development for Alzheimer's disease - Frontiers

Therefore, tau protein is regarded as a promising target for AD. Tau pathology has a greater impact on the cognitive decline progression of AD ...

Drug Discovery for Neurodegenerative Disorders - BioTechniques

Some proposed biomarkers and drug targets are TREM2, GFAP, MCP-1, MAPK1, VEGFR1, and FGFR1. Targeting these kinds of molecules is predicted to ...

Genipin and pyrogallol: Two natural small molecules targeting the ...

Alzheimer's disease (AD) is characterized by the aggregation of disordered proteins, such as amyloid beta (Aβ) and tau, leading to neurotoxicity and disease ...

Small molecule C381 targets the lysosome to reduce ... - PNAS

The resulting small molecule from this study represents a potential treatment for neurodegenerative diseases as well as a research tool for the ...

Defining the Neural Kinome: Strategies and Opportunities for Small ...

Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases. Click to copy ...

Neuroinflammation inhibition by small-molecule targeting USP7 ...

Collectively, our findings provide an attractive future direction for neurodegenerative disease therapy by inhibiting microglia-mediated ...

Potential of Therapeutic Small Molecules in Apoptosis Regulation in ...

Neurodegenerative diseases (NDs) are a group of diseases that are commonly characterized by the slow progressive loss of neurons in the central nervous system ( ...

A novel class of drug candidates for neurodegenerative diseases

The technology combines two highly selective molecules, each of which was individually designed to target and disrupt pathological forms of ...

Small molecule enhancers of autophagy for neurodegenerative ...

Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, prion diseases and ...

Repurposing small-molecule drugs for modulating toxic protein ...

Repurposing drugs for modulating toxic protein aggregation is a promising strategy in neurodegenerative diseases. Abstract. Neurodegenerative diseases (NDs) are ...

Neurodegeneration Targets - Discovery On Target

While small molecule-based treatment options will be highlighted because they are critical for diseases with a high population burden, the agenda will likely ...

New therapies on the horizon: Targeted protein degradation in ...

Importantly, small-molecule protein degraders specifically target and remove pathogenic proteins from central nervous system cells without the ...