polygenic risk scores predict hypertension onset and cardiovascular ...

Polygenic Risk Scores Predict Hypertension Onset and ... - PubMed

We demonstrate that genetic information improves hypertension risk prediction. BP PRSs together with traditional risk factors could improve prediction of ...

Polygenic Risk Scores Predict Hypertension Onset and ...

Systolic and diastolic blood pressure polygenic risk scores improved clinical risk prediction of hypertension, increasing the C statistics by ...

Polygenic Risk Scores Predict Hypertension Onset and ...

In FINRISK, systolic and diastolic BP PRSs improved clinical risk prediction of hypertension (but not CVD), increasing the C statistics by 0.7% (95% CI, 0.3–1.1) ...

Polygenic risk scores associate with blood pressure traits across the ...

We found that individuals with high PRSs were at increased risk of cardiovascular and cerebrovascular diseases, as well as all-cause mortality, indicating that ...

polygenic risk scores predict hypertension onset and cardiovascular ...

Compared to having an average PRS, elevated PRS was associated with up to 2.3-fold risk of hypertension and an 11-year earlier disease onset (Figure). In ...

BP Polygenic Risk Scores May Complement Measured BP for CVD ...

Now, researchers at Massachusetts General Hospital have determined that BP polygenic risk scores (PRS) predict new-onset CVD in middle-aged ...

Risk Prediction using Polygenic Risk Scores for Prevention of Stroke ...

Here we review the current state of the field of polygenic risk scores for CVD including stroke, and their potential to improve CVD risk prediction. We present ...

Evaluating the use of blood pressure polygenic risk scores across ...

These BP PRSs are associated with BP phenotypes, including rate of BP increase, and have been shown to predict incident coronary heart disease ...

Polygenic risk score adds to a clinical risk score in the prediction of ...

A cardiovascular disease polygenic risk score (CVD-PRS) can stratify individuals into different categories of cardiovascular risk, but whether ...

Dissecting the Polygenic Basis of Primary Hypertension - Frontiers

Recently, PRS associated with incident hypertension in a population based-cohort with the highest 2.5% PRS had a 2.3-fold risk of hypertension ...

Polygenic risk scores predict hypertension onset and cardiovascular ...

Polygenic risk scores predict hypertension onset and cardiovascular risk. F. C. Vaura, A. Kauko, K. Suvila, A. S. Havulinna, N. Mars, V. V. Salomaa, FinnGen ...

Highly elevated polygenic risk scores are better predictors of ...

Several polygenic risk scores (PRS) have been developed for cardiovascular risk prediction ... cardiovascular disease is improved for early onset ...

Polygenic Risk Scores Predict Hypertension Onset and ... - OUCI

In FINRISK, systolic and diastolic BP PRSs improved clinical risk prediction of hypertension (but not CVD), increasing the C statistics by 0.7% (95% CI, 0.3–1.1) ...

Integration of polygenic risk score with non-genetic determinants

This study also reported that PRS substantially improved the percentage of variance explained for both SBP (11.37%) and DBP (12.12%) compared ...

POLYGENIC RISK SCORES PREDICT HYPERTENSION ONSET ...

Inclusion of blood pressure PRSs did not improve the clinical CVD risk score. Conclusions We demonstrated that genetic information improves ...

Utility of a Systolic Blood Pressure Polygenic Risk Score With ...

Importance The clinical utility of polygenic risk scores (PRS) for blood pressure (BP) response to antihypertensive treatment (AHT) has not been ...

Polygenic risk scores in cardiovascular risk prediction - PLOS

Our results suggest that addition of PRSs to conventional risk factors can modestly enhance prediction of first-onset CVD and could translate into population ...

Measured Blood Pressure, Genetically Predicted ... - JAMA Network

Meaning Blood pressure polygenic risk scores may complement measured blood pressure to achieve earlier and targeted cardiovascular disease ...

Polygenic Risk Scores for Predicting Adverse Outcomes After ...

8. Vaura, F ∙ Kauko, A ∙ Suvila, K ... Polygenic risk scores predict hypertension onset and cardiovascular risk. Hypertension. 2021; 77 ...

Genomic risk prediction of cardiovascular diseases among type 2 ...

Background: Polygenic risk score (PRS) has proved useful in predicting the risk of cardiovascular diseases (CVD) based on the genotypes of an individual, but ...