siRNA Delivery to Cancer Cells by Exosomes

Preparation of Exosomes for siRNA Delivery to Cancer Cells - PubMed

This work establishes an isolation protocol to achieve high yield and high purity of exosomes for siRNA delivery.

Exosome-mediated delivery of siRNA molecules in cancer therapy

Exosomes are effective nanosystems for siRNA delivery, demonstrating superior gene knockdown and associated anticancer therapeutic effects (Lin et al., 2021; ...

Preparation of Exosomes for siRNA Delivery to Cancer Cells - PMC

This work establishes an isolation protocol to achieve high yield and high purity of exosomes for siRNA delivery.

Exosomes are natural carriers of exogenous siRNA to human cells ...

The exosome-delivered siRNAs were effective at causing post-transcriptional gene silencing in recipient cells. Moreover, the exosome-delivered ...

Targeted delivery of RNAi to cancer cells using RNA-ligand ...

Exosome is an excellent vesicle for in vivo delivery of therapeutics, including RNAi and chemical drugs. The extremely high efficiency in cancer regression ...

Patient-Derived Exosomes as siRNA Carriers in Ovarian Cancer ...

Intraperitoneal treatment suppressed the c-Met downstream targets in cancer cells and prolonged mouse survival. The synthesized siRNAs were successfully and ...

Preparation of Exosomes for siRNA Delivery to Cancer Cells - JoVE

Watch this JoVE video on Preparation of Exosomes for siRNA Delivery to Cancer Cells.

Exosomes-delivered PD-L1 siRNA and CTLA-4 siRNA protect ...

Exosomes containing PD-L1 siRNA and CTLA-4 siRNA repressed malignant features of CRC cells and restrained tumor growth and activated tumor immune responses in ...

Exosomes as bio-inspired nanocarriers for RNA delivery

In another study, SGC-7901 and HEK293T cells transfected with siRNA and the released HGF siRNAs loaded exosomes were found to be able to ...

Exosomes for siRNA Delivery - Subcellomics - Creative Proteomics

Lipofectamine-combined siRNAs are first incubated with the extracellular vesicles and then siRNA-loaded exosomes are cultured together with the target cells. In ...

siRNA Delivery to Cancer Cells by Exosomes | Protocol Preview

siRNA Delivery to Cancer Cells by Exosomes | Protocol Preview · Comments. thumbnail-image. Add a comment...

A targeted siRNA‐loaded PDL1‐exosome and functional evaluation ...

In conclusion, exogenous siRNA can be loaded and delivered into target cells using targeted exosomes. Selective gene silencing can inhibit tumor ...

iRGD-modified exosomes-delivered BCL6 siRNA inhibit ... - Frontiers

Although siRNA can be used to suppress specific oncogenes in various cancers, delivering siRNAs into specific tissues and cells can be hampered ...

Arrowtail RNA for Ligand Display on Ginger Exosome-like ... - Nature

Recently, we reported the control of RNA orientation to decorate human derived exosome with cell targeting ligands for specific delivery of ...

Preparation of Exosomes for siRNA Delivery to Cancer Cells

This protocol offers a standard procedure for developing siRNA-loaded exosomes for efficient delivery to cancer cells in vitro and offers a combination of ...

Preparation of Exosomes for siRNA Delivery to Cancer Cells - JoVE

Watch this Scientific Journal Video about Preparation of Exosomes for siRNA Delivery to Cancer Cells at JoVE.com.

Preparation of Exosomes for siRNA Delivery to Cancer Cells

... Among other therapeutic agents, siRNAs are very effective in regulating the targeted genes but prone to degradation. To perform systemic and bio-compatible ...

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells Available Online. Click for viewing options.

Engineered exosomes for the delivery of PD-L1 siRNA for lung ...

Small interfering RNA (siRNA) against PD-L1 presents a compelling alternative to antibody treatment to reduce PD-L1 presentation on cancer cells ...

Preparation of Exosomes for siRNA Delivery to Cancer Cells

The encapsulation efficiency of siRNA in exosomes is ~ 10-20%. Forty percent of the cells show positive signals for Atto655 at 24 h post- ...