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Subgroup analyses in randomised controlled trials - PubMed

While it is generally recognised that subgroup analyses can produce spurious results, the extent of the problem is almost certainly under-estimated.

Interaction analysis of subgroup effects in randomized trials - Nature

Subgroup analysis aims to identify subgroups (usually defined by baseline/demographic characteristics), who would (or not) benefit from an ...

On the interpretation of subgroup analyses in randomized trials

In randomized trials with subgroup analyses, the primary treatment or intervention of interest is randomized but the secondary factors ...

Subgroup analysis in randomised controlled trials - The Lancet

Subgroup analyses are important if there are potentially large differences between groups in the risk of a poor outcome with or without treatment.

Subgroup Analysis in Randomized Controlled Trials - ScienceDirect

Randomized clinical trials often use subgroup analyses to explore whether a treatment is more or less effective in a particular patient subgroup.

Subgroup analysis in randomised controlled trials: importance ...

Subgroup analyses are important if there are potentially large differences between groups in the risk of a poor outcome with or without treatment.

Subgroup Analysis in Randomized Controlled Trials

Randomized clinical trials often use subgroup analyses to explore whether a treatment is more or less effective in a particular patient subgroup ...

Subgroup analysis in randomised controlled trials - ScienceDirect.com

Subgroup analyses are important if there are potentially large differences between groups in the risk of a poor outcome with or without treatment.

Subgroup analyses in randomized clinical trials: value and ...

Subgroup analyses in randomized clinical trials: value and limitations. Review #3 on important aspects of randomized clinical trials in cardiovascular ...

When to believe a subgroup analysis: revisiting the 11 criteria - Nature

The validity of a subgroup analysis largely depends on reporting all of the conducted subgroup analyses regardless of their statistical ...

What a Clinician Ought to Know: Subgroup Analyses

WHAT ARE SUBGROUP ANALYSES? ... In randomized clinical trials, subgroup analyses evaluate the treatment effect (e.g., a hazard ratio [HR]) for a specific endpoint ...

Evaluation of Planned Subgroup Analysis in Protocols of ...

This cross-sectional study compares randomized clinical trial protocols to assess the prevalence and reporting quality of planned subgroup ...

A systematic review of subgroup analyses in randomised clinical ...

Corresponding investigations are generally based on the assumption that certain subgroups of patients may benefit more or less from a studied ...

Full article: Subgroup Analyses in Randomized Clinical Trials

Subgroup analyses should be systematically carried out to identify and quantify predictable and new safety problems that are more commonly observed in subgroups ...

How to understand subgroup analysis in clinical studies

Subgroup analyses in randomized phase III trials of systemic treatments ... Subgroup analysis in randomised controlled trials: importance,.

Same Old Challenges in Subgroup Analysis—Should We Do More ...

With an average number of 9 subgroup analyses per oncology trial, these subgroup analyses run a high risk of being misled—and misleading their ...

The influence of study characteristics on reporting of subgroup ...

They also used explicit criteria to determine whether a randomised controlled trial reported subgroup analyses. Logistic regression was used to ...

Statistics in Medicine — Reporting of Subgroup Analyses in Clinical ...

By “subgroup analysis,” we mean any evaluation of treatment effects for a specific end point in subgroups of patients defined by baseline characteristics. The ...

Subgroup analyses in randomized controlled trials frequently ...

Background and Objectives: To investigate how subgroup analyses of published Randomized Controlled Trials (RCTs) are performed when subgroups ...

Understanding of interaction (subgroup) analysis in clinical trials

In randomized clinical trials (RCTs), this type of analysis is typically referred to as subgroup analysis. Although interaction (or subgroup) ...