[PDF] Looking beyond drivers and passengers in cancer genome ...

Evaluating the evaluation of cancer driver genes - PNAS

Because passenger gene mutations will also be fixed in any cell that expands due to a driver gene mutation, statistical evaluation in patient cohorts is ...

Mutation Signatures Depend on Epigenomic Contexts - Cell Press

De, S. ∙ Ganesan, S. Looking beyond drivers and passengers in cancer genome sequencing data. Ann. Oncol. 2016; 28:938-945.

Distinguishing between cancer driver and passenger gene ...

We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, ...

Genome-wide mapping of somatic mutation rates uncovers drivers ...

Identification of cancer driver mutations that confer a proliferative advantage is central to understanding cancer; however, searches have ...

Individualized discovery of rare cancer drivers in global network ...

Therefore, a cancer cell genome usually represents a mixture of driver and passenger mutations (Torkamani et al., 2009). Apart from the boosting ...

Tug-of-war between driver and passenger mutations in cancer and ...

Precancerous cells acquire a few key mutations that drive rapid population growth and carcinogenesis. Cancer genomics demonstrates that these ...

Discovery through clinical sequencing in oncology - CDC stacks

Beyond its role in driving clinical trial enrollments and guiding therapy in individual patients, large-scale clinical genomics in oncology also ...

Moving From Mutation to Actionability | American Society of Clinical ...

Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine. Genome Med. 2014;6:5. Go to Citation.

Identifying modules of cooperating cancer drivers - EMBO Press

However, CRSO models can include additional alteration types, such as gene fusions and aneuploidies. In order to calculate passenger probabilities, mutations ...

Understanding oncogenicity of cancer driver genes and mutations in ...

One of the key challenges of cancer biology is to catalogue and understand the somatic genomic alterations leading to cancer.

Computational approaches to identify functional genetic variants in ...

As cancer genome projects are moving toward sequencing whole genomes, more non-coding driving mutations will likely be discovered. To facilitate such.

RNA allelic frequencies of somatic mutations encode ... - bioRxiv

gene contained within the CGC list. 324. 325. RNA VAF can predict driver and passenger mutations within established cancer genes. 326. 327.

Driver mutations in oncogenesis

Since there are many mutations occurring in the cancer cell genome, it is a challenge to identify specifically the driver mutation from all other passenger ...

Passenger hotspot mutations in cancer driven by APOBEC3A and ...

APOBEC-generated mutations outside of stem-loops were more likely to be cancer driver mutations, providing a genomic context for separating cancer driver from ...

Rogers, MF, Gaunt, TR, & Campbell, ICG (2020). Prediction of

CScape-somatic: distin- guishing driver and passenger point mutations in the cancer genome. ... Wesme: uncovering mutual exclusivity of cancer drivers and beyond.

ANALYSIS - Michor Lab

Looking beyond drivers and passengers in cancer genome sequencing data. ... identify new driver mutations in gastric cancer. Nat. Genet. 46 ...

Genetics of common complex diseases

Large-scale genome sequencing of all major cancer types has enabled characterization of driver and passenger mutations, thereby facilitating the ...

Passenger mutations can accelerate tumour suppressor gene ...

Carcinogenesis is an evolutionary process whereby cells accumulate multiple mutations. Besides the 'driver mutations' that cause the disease ...

Cumulative Haploinsufficiency and Triplosensitivity Drive ... - CORE

and are likely to be cancer drivers rather than passengers. If so, we should ... Pancreatic Cancer Genome Initiative; ICGC Breast Cancer Consortium; ICGC.

Simultaneous Identification of Multiple Driver Pathways in Cancer

Distinguishing the somatic mutations responsible for cancer (driver mutations) from random, passenger mutations is a key challenge in cancer genomics.