A Multi|Omics Analysis Revealing Novel CpG Sites and Their ...

Multi‐Omics Factor Analysis—a framework for unsupervised ...

Methylation data were transformed to M‐values, and we extracted the top 1% most variable CpG sites excluding sex chromosomes (D = 4,248). We included ...

Novel DNA methylation loci and genes showing pleiotropic ...

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. ... analysis revealing over 60 novel age-associated CpG sites.

Genome‐wide association and multi‐omics studies identify MGMT ...

Furthermore, promoter capture Hi-C analyses revealed long-range interactions of the MGMT promoter with MGMT SNPs and CpG sites. Discussion.

A longitudinal and transancestral analysis of DNA methylation ...

A total of 7269 (82.1%) of meQTL did not contain CpG-SNPs. Gene set enrichment analysis (GSEA) of the 3871 unique genes associated with the CpG sites revealed ...

Gene Set Based Integrated Methylome and Transcriptome Analysis ...

the other containing 33 genes with hypomethylated CpG sites in their promoter region, were differentially ... List of 36 Novel Cigarette Smoking-Related CpG Sites ...

Methylome and transcriptome profiling of giant cell arteritis ...

Our results revealed profound alterations in the methylation and transcriptomic profiles of monocytes from GCA patients, uncovering novel genes and pathways ...

Comprehensive analysis of bulk and single-cell RNA sequencing ...

DNA methylation analysis revealed specific CpG sites associated with SLFN5 expression. ... Comprehensive omics analysis of a novel small ...

Manhattan plot (a) and volcano plot (b) of CpG sites differentially...

Our analysis allowed us to reveal novel putative COPD-associated genes and to analyze their relationships, both at the transcriptomics and epigenomics ...

CpG Site-Based Signature Predicts Survival of Colorectal Cancer

Network analysis revealed molecular networks enriched for CpG sites mapped to ... clonality of driver genes revealing their clinical ...

Integrative co-methylation network analysis identifies novel DNA ...

INTRODUCTION: DNA methylation is a key epigenetic marker, and its alternations may be involved in Alzheimer's disease. CpGs sharing similar biological ...

Integrated multi-omics reveal epigenomic disturbance of assisted ...

Second, the overlapping sites among the selected CpG sites from the 5 groups were taken into consideration for further analysis. Therefore ...

Multiomics Screening Identified CpG Sites and Genes That Mediate ...

Colocalization analysis revealed CpG sites that their mQTLs overlap with the SNPs of cardiometabolic traits. ... Integrative Analysis of Omics Summary Data ...

Integrative multi-omic cancer profiling reveals DNA methylation ...

Overall, we detected 5,570 hypermethylated CpG sites associated with mRNA downregulation of 2,549 genes,. 889 hypermethylated CpG sites ...

Multi-Omics Profiling for Health - Molecular & Cellular Proteomics

2-DE, 2-Dimensional Electrophoresis; ATAC, Assay for Transposase-Accessible Chromatin; CAGE, Cap Analysis Gene Expression; DNMT1, DNA Methyl Transferase one; ...

Whole genome DNA methylation: beyond genes silencing | Oncotarget

DNA methylation is widely analyzed in the CpG context, due to the fact that 80 % of methylation events occur at CpG sites in mammalian genomes.

Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic ...

A subset of colorectal cancers has an exceptionally increased frequency of hypermethylation at certain CpG islands, forming a distinct subtype referred to as ...

Synthetic CpG islands reveal DNA sequence determinants of ... - eLife

Genomic landmarks, known generically as 'CpG islands', program chromatin structure via their richness in the dinucleotide CG and their ...

Multi‐omics analysis reveals epigenetically regulated processes ...

Furthermore, the CpGs were connected to their associated genes through chromatin interaction loops. These findings suggest that the expression ...

Genome‑wide methylation analysis reveals differentially methylated ...

Therefore, it is reasonable to speculate that there might be a link between intergenic CpG site methylation levels of EGFR and SLC19A1 DMRs, ...

Multiomics Data Analyses Identified CpG Sites and Genes That ...

... CpG site on a trait. Table 1. Colocalization analysis revealed CpG sites that their mQTLs overlap with SNPs of cardiometabolic traits. Trait.