A sustained CYCLINB1

Targeting cyclin B1 inhibits proliferation and sensitizes breast ...

Uncontrolled cell proliferation, which is associated with the loss of the proper cell cycle control, is a prominent feature in these cancers.

Anti-Cyclin B1 Antibody, clone GNS3 (8A5D12) | 05-373

Anti-Cyclin B1 Antibody, clone GNS3 (8A5D12) is a Mouse Monoclonal Antibody for detection of Cyclin B1 also known as G2/mitotic-specific cyclin B1 & has ...

A sustained CYCLINB1;1 and STM expression ... - BVS

A sustained CYCLINB1;1 and STM expression in the neoplastic tissues induced by Rhodococcus fascians on Arabidopsis underlies the persistence of the leafy ...

ERK/MAPK Pathway Is Required for Changes of Cyclin D1 and B1 ...

PD98059, a speci残 inhibitior of MEK1, partially prevented the increase in cyclin D1 caused by PMA and fully reversed the down-regulation of cyclin B1 protein ...

The Expression of p21/WAF-1 and Cyclin B1 Mediate Mitotic Delay ...

Initiation and maintenance of cell cycle arrest is regulated by a group of proteins known as the cyclins which function by coupling to their corresponding ...

Fertilization differently affects the levels of cyclin B1 and M-phase ...

Chromatin of maturing mouse oocytes fertilized by four spermatozoa (A) or a single spermatozoon (B) and subsequently cultured 4 h in the presence of ...

Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis ...

Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. Authors: Ping ...

1 and STM expression in the neoplastic tissues induced by ... - OUCI

A sustained CYCLINB1;1 and STM expression in the neoplastic tissues induced by Rhodococcus fascians on Arabidopsis underlies the persistence of the leafy gall ...

Nuclear-cytoplasmic compartmentalization promotes robust timing of ...

Upon cyclin B1-Cdk1 activation, the sensor domain is phosphorylated by Cdk1 and bound by the ligand domain, thereby inducing a conformational ...

Elevated cyclin B1 protein levels sustain the SAC. (A) RPE1 WT ...

Download scientific diagram | Elevated cyclin B1 protein levels sustain the SAC. (A) RPE1 WT, CDC14B KO, and CDC14A KO cells were treated with 3.3 μM NOC ...

CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in ...

Abstract. Manganese superoxide dismutase (MnSOD), a major antioxidant enzyme within the mitochondria, is responsible for the detoxification of free radical.

Cyclin B1 stability is increased by interaction with BRCA1, and its ...

Germline BRCA1 mutations predispose women to breast and ovarian cancer. BRCA1, a large protein with multiple functional domains, ...

Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene ...

Replication of minute virus of mice (MVM) induces a sustained cellular DNA damage response (DDR) which the virus then exploits to prepare the nuclear ...

Distinct Sequence Elements of Cyclin B1 Promote Localization to ...

The mitotic cyclins promote cell division by binding and activating cyclin-dependent kinases (CDKs). Each cyclin has a unique pattern of subcellular ...

Sustained spindle-assembly checkpoint response requires de novo ...

The exogenous expression of Cyclin B1 substantially rescued the mitotic phenotype in nocodazole cells treated with the inhibitors of transcription and ...

Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1 ...

Abstract. Purpose: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive breast cancer. However, resistance inevitably occurs.

Mechanisms Governing Maintenance of Cdk1/Cyclin B1Kinase ...

FIG. 9. Model for activation of Cdk1/cyclin B1 complexes in HCMV-infected cells. (A) The addition of inhibitory phosphates to the catalytic subunit, Cdk1, is ...

Phosphorylation of XIAP by CDK1–cyclin-B1 controls mitotic cell death

XIAP is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1–cyclin-B1 at S40. Mutation of S40 to a ...

Spatiotemporal control of mitotic exit during anaphase by an aurora ...

Failure to degrade B-type Cyclins during anaphase prevented mitotic exit in a Cdk1-dependent manner. Cyclin B1-Cdk1 localized at the spindle ...

Sustained Metaphase Arrest in Response to Ionizing Radiation in a ...

... cyclin B1, indicating a sustained metaphase arrest. Panel B: The fate of HCC2279 cells after exposure to a dose of 10 Gy was followed in a time lapse study ...