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Airway smooth muscle in the pathophysiology and treatment of asthma


What is the pathophysiology of asthma? - MedicalNewsToday

Reversibility · increased thickness of the smooth muscle in the airways · an increased number of airway smooth muscle cells · increased airway wall ...

Airway smooth muscle pathophysiology in asthma | Request PDF

The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and constitutes an important target for treatment.

Asthma: Practice Essentials, Background, Anatomy

Varying degrees of mononuclear cell and eosinophil infiltration, mucus hypersecretion, desquamation of the epithelium, smooth muscle hyperplasia, and airway ...

Increased airway smooth muscle cells in asthma: mechanisms and ...

In addition, an increased airway smooth muscle mass at preschool age is predictive of asthma at school age (6), and is associated with decreased lung function, ...

Airway smooth muscle pathophysiology in asthma - SUNY New Paltz

The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and constitutes an important target for treatment.

Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma

Rationale: Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells ...

Role of Airway Smooth Muscle Cells in Asthma Pathology

Airway smooth muscle (ASM) cells have been shown to play an important role in bronchial asthma. As the research progresses, the mechanism ...

Targeting Airway Smooth Muscle Hypertrophy in Asthma - JAA

New approaches in asthma therapy are needed. Recently, the role of airway smooth muscle hypertrophy as a significant component of asthmatic ...

Airway Smooth Muscle and Asthma - MDPI

In asthma, the key end-effector of acute airway narrowing is the contraction of the ASM cell driven by myosin motors exerting their mechanical ...

Airway smooth muscle and fibroblasts in the pathogenesis of asthma

Airway smooth muscle and subepithelial fibroblasts are likely to be key players in the asthmatic airway pathophysiology through their interaction with each ...

Pathogenesis of asthma - UpToDate

Smooth muscle · Mucus plugging · Bronchial hyperresponsiveness · Clinical ... asthma and its treatment. Discussions of the genetics, clinical risk factors ...

Understanding asthma pathophysiology, diagnosis, and management

Airway capillaries may dilate and leak, increasing secretions, which in turn causes edema and impairs mucus clearance. (See How bronchospasm ...

Cells | Special Issue : Airway Smooth Muscle and Asthma - MDPI

It has been long believed that dysfunction of ASM contraction, proliferation, and immunomodulation contributes to the pathophysiology of asthma, by inducing ...

Network and co-expression analysis of airway smooth muscle cell ...

Airway smooth muscle (ASM) is known for its role in asthma exacerbations characterized by acute bronchoconstriction and remodeling.

Mast cell regulation of airway smooth muscle function in asthma

Mast cells play a significant role in the pathophysiology of asthma due to their ability to release a host of pleiotropic autacoid mediators, proteases and ...

Asthma Pathophysiology

Induced by airway inflammation. Bronchoconstriction- Bronchial smooth muscle contraction that quickly narrows the airways in response to exposure to a.

Pathophysiology of severe asthma: We've only just started - King

These pathological changes result in reduced baseline lung function (in some cases) and severe, excessive airway narrowing when the smooth ...

Airway remodeling in asthma - JCI

Asthma used to be considered largely in terms of the abnormal contraction of airway smooth muscle (bronchospasm), which was presumed to be due to an intrinsic ...

Pathophysiology of asthma - Wikipedia

Asthma is a common pulmonary condition defined by chronic inflammation of respiratory tubes, tightening of respiratory smooth muscle, and episodes of ...

Essential role of smooth muscle Rac1 in severe asthma-associated ...

Background Severe asthma is a chronic lung disease characterised by inflammation, airway hyperresponsiveness (AHR) and airway remodelling.