An introduction to multiplicity issues in clinical trials

Multiplicity Considerations in Clinical Trials - SIREN Network

However, proper treatment of multiplicity issues also plays an important role in exploratory trials (e.g., dose-finding phase 2 trials) aimed at.

Multiplicity adjustments in parallel-group multi-arm trials sharing a ...

Multiplicity is a major consideration in the analysis of clinical trials. It occurs when multiple significance tests are carried out, increasing the family-wise ...

Handling Multiplicity in Clinical Trials

We hope the reader will gain an appreciation for the underlying problem of multiplicity and understand different approaches for cor- recting for these multiple ...

Prevalence of Multiplicity and Appropriate Adjustments Among ...

Multiplicity refers to the “potential inflation of type I error rate as a result of multiple testing, for example because of multiple subgroup ...

An introduction to multiplicity issues in clinical trials: the what, why ...

An introduction to multiplicity issues in clinical trials: the what, why, when and how. Li, G.; Taljaard, M.; Van den Heuvel, E.R.; Levine, M.Ah.; Cook, D.J. ...

An introduction to multiplicity issues in clinical trials

An introduction to multiplicity issues in clinical trials: the what, why, when and how.-article.

Multiplicity Issues in Clinical Trials - ResearchGate

Relevant textbooks, articles, an international conference, guidances, and a web site are provided as references. ResearchGate Logo. Discover the world's ...

Multiplicity in clinical trial: An ignored concept

Multiplicity is an inevitable issue in the interpretation of clinical trial data. It is defined as the potential inflation of type-I error rate (or alpha level)

Key Multiplicity Issues in Clinical Trials - online donation form

Chapter 5: Multiplicity adjustment methods. Introduction to multiplicity problems arising in clinical trials, popular multiple testing procedures and ...

Handling Multiplicity in Clinical Trials

We hope the reader will gain an appreciation for the underlying problem of multiplicity and understand different approaches for correcting for these multiple ...

Multiplicity issues in clinical trials for multiple groups - Cross Validated

Let's say we design a RCT for two different populations and want to test an intervention vs a control. It could be adults and children, male and female, etc.

Multiplicity Problems in the Clinical Trial and Some Statistical ...

An introduction to multivariate statistical analysis, 2nd edition. New York: Wiley. MATH Google Scholar. Armitage, P. and Parmar, M. (1986). Some approaches to ...

Multiplicity in clinical trial: An ignored concept | Semantic Scholar

2017. TLDR. An introduction to multiple testing issues in clinical trials is provided, and options for carrying out multiplicity adjustments in terms of trial ...

Online training - Mediana

An 8-part online training course on advanced multiplicity problems in clinical trials: Introduction. Module A. Clinical trial examples (Phase III trials with ...

Multiplicity Problems in Clinical Trials – A Regulatory Perspective

It is a unique document ever tried at the FDA, written by an FDA committee of statistical and clinical experts. • It is written in a non- ...

Quick Guide to Biostatistics in Clinical Research: Multiplicity - Enago

This problem can also be introduced if there are many subgroups in a clinical trial. Multiplicity Adjustment. Multiple testing can be done ...

Key Multiplicity Issues in Clinical Trials (Part I) - YouTube

The online training course gives a comprehensive overview of traditional multiplicity problems with a single source of multiplicity in clinical trials.

Understand and master multiplicity in practical situations

Huque, M.F., Dmitrienko, A., D'Agostino, R.B. (2013). Multiplicity issues in clinical trials with multiple objectives. Statistics in Biopharmaceutical Research.

Multiplicity Considerations in Clinical Trials | NEJM

A number of statistical approaches can facilitate the precise interpretation of clinical trial results. View Full Text. Notes. Disclosure forms ...

Guideline on multiplicity issues in clinical trials - Benjamin Hofner

The Paul-Ehrlich-Institut is an Agency of the. German Federal Ministry of Health. (Draft) Guideline on multiplicity issues in clinical trials.