Assessing biological and technological variability in protein levels ...

Biological versus Technical Variation. a Biological variance is...

technical variance from publication: Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women ...

Uncovering the Depths of the Human Proteome: Antibody-based ...

Recent breakthroughs in multiplex, antibody-based, proteomics technologies now enable the simultaneous quantification of thousands of proteins at as low as sub ...

Population-scale proteogenomics - Olink

Next-generation high-throughput proteomics empowers genetically-informed assessment of protein causality and the confident identification of novel drug targets.

MS-Based Proteomics of Body Fluids: The End of the Beginning

Suitable routine detectability by MS is more likely if proteins were implicated as biomarkers by this technology in the first place. Marker ...

Technical Performance Evaluation of Olink Proximity Extension ...

Proteins with large within group variability or with small to medium differences between diagnostic groups are particularly impacted by ...

Posters - Resources - Life Science Research - SomaLogic

A primary source of variability comes from inherent issues in the actual technology used to measure the protein levels in a sample, but additional variability ...

Assessing biological variation and protein processing in primary ...

This paper describes a method that allows for fully automated quantitative proteome analysis; involving desalting, triplex stable isotopic dimethyl labeling ...

Performance Metrics for Proteomics | NIST

The NCI's Clinical Proteomic Technologies for Cancer (CPTC) have identified technical variability as a major roadblock in the search for protein markers of ...

Global variability analysis of mRNA and protein concentrations ...

In-depth knowledge of protein concentration variability in single tissue types would enable systems biology to deliver results that better ...

Quartet protein reference materials and datasets for multi-platform ...

Quantitative evaluation based on the SNR, which ranged from 0.6 to 28, demonstrated substantial variation in the proteomic detection level of ...

Cellular control of protein levels: A systems biology perspective

For most samples and organisms, substantial across-gene correlations have been observed. Typically, about 40% of the variability in protein ...

Plasma protein biomarkers for early prediction of lung cancer

For samples 1–3 years pre-diagnosis, 240 proteins were significantly different in cases; for 1–5 year samples, 117 of these and 150 further ...

Body Fluid Biomarkers | Green Lab - UCSF

... protein, are studied to assess disease activity and ... technology to enable highly sensitive and precise measurement of biomarkers in biological samples.

Proteomic profiling platforms head to head: Leveraging genetics and ...

Alternatively, comparison of available platforms to one another offers an opportunity for high-throughput assessment. Earlier comparisons have ...

Analytical techniques for multiplex analysis of protein biomarkers

This allows the measurement of the concentration of molecules in biological fluids or biological systems [Citation9]. The technology was originally ...

Preprocessing of Protein Quantitative Data Analysis

By comparing mean or median protein abundances between groups and evaluating the variability within and between groups, hypothesis testing enables researchers ...

Plasma proteomic biomarker signature of age predicts health ... - eLife

Here, a proteomic analysis of 1301 plasma proteins was conducted in 997 individuals between 21 and 102 years of age. We identified 651 proteins ...

Are We There Yet? Assessing the Readiness of Single-Cell ...

Many technologies have been used to study single cells, including mass spectrometry-based single-cell proteomics (SCP). SCP has seen a lot of ...

The Human Protein Atlas

The atlas for all human proteins in cells and tissues using various omics: antibody-based imaging, transcriptomics, MS-based proteomics, and systems biology ...

Coefficients of Variation - SomaLogic

Low coefficients of variation allow detection of changes in the abundance of specific proteins in a complex biological sample.