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Axonal sensitivity and block dynamics


A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic ...

Proper axon guidance is essential in both the developing nervous system and the nerve regeneration process so as to insure integrity and ...

Axonal degeneration in chemotherapy-induced peripheral ...

... dynamics may negatively affect both anterograde and retrograde axonal transport. ... Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.

Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects ...

However, previous work did not resolve whether mutant huntingtin affects global axonal transport or only a subset of cargoes, nor did it resolve ...

En masse in vitro functional profiling of the axonal ... - PNAS

TTX resistance was observed exclusively among the static neurons and was present in 47% of them, independent of capsaicin sensitivity. Vibration neurons made up ...

A generative model of the connectome with dynamic axon growth

Our model is sufficiently sensitive to capture subtle interindividual differences in axonal outgrowth between healthy adults. Our results are significant ...

Dynamics and sensitivity analysis of high-frequency conduction block

... block phenomenon. Hypothesis 2 was investigated using a spectral analysis of the channel gating variables in a single-fiber axon model. The results of this ...

Myelinated Central Vertebrate Axon Lacks Voltage ... - Science

... block voltage-sensitive potassium conductance. Analys ... YEH, J.Z., DYNAMICS OF AMINOPYRIDINE BLOCK OF POTASSIUM CHANNELS IN SQUID ...

Action potential - Wikipedia

... sensitivity and different temporal dynamics. The most intensively studied ... "Dynamic electrical characteristics of the squid axon membrane". Arch ...

Peripherin is a biomarker of axonal damage in peripheral nervous ...

... axonal injury as well as having dynamic sensitivity. It also does not seem to rise with older age, unlike NfL, simplifying interpretation of normative ...

Anaesthesia recommendations for Giant axonal neuropathy

The choice of neuromuscular blocking agent must be considered carefully. Patients with. GAN have denervated muscle that may result in increased sensitivity to ...

Regulation of Microtubule Dynamics in Axon Regeneration

Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration. We ...

Impaired dynamic interaction of axonal endoplasmic reticulum and ...

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is caused by mutations in the SMN1 gene. SMA is ...

[PDF] Beyond faithful conduction: Short-term dynamics ...

Beyond faithful conduction: Short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.

General Approach to Peripheral Nerve Disorders

axonal degeneration. This can be read- ily extrapolated to the ... sensitivity of 90%, a specificity and positive predictive value of ...

sensory axonal neuropathy: Topics by Science.gov

... axonal transport, and altered ion channel dynamics and ... axonal mechanical sensitivity (AMS) along intact nociceptor axons and disrupts axonal transport.

The relationship between neuron-specific enolase, high sensitivity C ...

Due to the high content of NSE in the axons of peripheral nerves, long-term neuropathy leads to Wallerian degeneration, axonal destruction, and ...

Inflammation Induces Ectopic Mechanical Sensitivity in Axons of ...

The time course of the resultant hypersensitivity was not directly related to the time course of the axonal mechanical sensitivity. Ectopic axonal mechanical ...

Mitochondrial Dynamics Decrease Prior to Axon Degeneration ...

We suggest the alterations in mitochondrial structure and dynamics are early events which lead to axon degeneration and cytNmnat1 blocks axon ...

(PDF) Quantitative Analysis of Axonal Branch Dynamics in the ...

However, blocking neuronal activity with TTX slightly increased the death rate, without a detectable change in the birth rate. Third, we show ...

Axonal Transport Impairment in Chemotherapy-Induced Peripheral ...

The high binding affinity of taxanes to β-tubulin, in addition to blocking mitosis, can perturb microtubule dynamics and stability, inducing microtubule ...