Beyond the unfolded protein response

Alterations of protein homeostasis in Alzheimer's disease

Alterations of protein homeostasis in Alzheimer's disease: beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response. Lim, Dmitry ...

controlling cell fate decisions under ER stress and beyond

... (UPR), an adaptive reaction that reduces unfolded protein load ... The unfolded protein response: controlling cell fate decisions under ER stress and beyond ...

Regulation of basal cellular physiology by the homeostatic unfolded ...

The major consequence of vastly expanded UPR signaling is the regulatory influence of cellular pathways that function well outside the realm of ...

controlling cell fate decisions under ER stress and beyond

ER stress is buffered by the activation of the unfolded protein response (UPR), a homeostatic signalling network that orchestrates the recovery of ER function, ...

Unfolded protein response - Lasker Foundation

The 2014 Albert Lasker Basic Medical Research Award honors two scientists for their discoveries concerning the unfolded protein response, ...

The Unfolded Protein Response: A Double-Edged Sword for Brain ...

These stress pathways rely on the proper function of the endoplasmic reticulum (ER) and the activation of the unfolded protein response (UPR), a cellular ...

[PDF] The Unfolded Protein Response and Cell Fate Control.

The unfolded protein response comprises a network of signalling pathways that reprogramme transcription, translation and protein modifications.

controlling cell fate decisions under ER stress and beyond - Ex Libris

ER stress is buffered by the activation of the unfolded protein response (UPR), a homeostatic signalling network that orchestrates the recovery of ER function, ...

An unfolded protein-induced conformational switch activates ... - eLife

ER-stress sensing mechanism of the unfolded protein response sensor/transducer IRE1 is conserved from yeast to mammals, where in mammals, ...

Pathways: Unfolded Protein Response | www.antibodies-online.com

Hetz: "The unfolded protein response: controlling cell fate decisions under ER stress and beyond." in: Nature reviews. Molecular cell biology, Vol. 13 ...

controlling cell fate decisions under ER stress and beyond

ER stress is buffered by the activation of the unfolded protein response (UPR), a homeostatic signalling network that orchestrates the recovery of ER function, ...

Mitochondrial unfolded protein response - Wikipedia

The UPRmt results from unfolded or misfolded proteins in mitochondria beyond the capacity of chaperone proteins to handle them. The UPRmt can occur either in ...

The Unfolded Protein Response in Health and Disease

... proteins occur. Research over the past decade has demonstrated that mutations in proteins or agents/conditions that disrupt protein folding adversely affect ...

The Unfolded Protein Response: From Stress Pathway to ... - Science

The ER responds to the burden of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction pathways, collectively termed the ...

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen ...

The unfolded protein response (UPR) is initiated by E2 in the endoplasmic reticulum after hours of treatment in endocrine-resistant breast cancer cells, thereby ...

Regulation of the unfolded protein response by noncoding RNA

Beyond its activation upon accumulation of misfolded proteins, the UPR can also be triggered by stress-independent mechanisms. For instance, the IRE1-XBP1 ...

Maintaining the factory: the roles of the unfolded protein response in ...

This is done in an attempt to move beyond a classical linear signal transduction paradigm, and visualize the plant UPR as a network that ...

Disclosing the role of XBP1s in Alzheimer's disease - OUCI

Duran-Aniotz, The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis, Mol.

Orchestrating the unfolded protein response in health and disease

These pathways, collectively termed the unfolded protein response (UPR) ... out of 1,800 births. However, a subgroup of affected individuals develop ...

controlling cell fate decisions under ER stress and beyond - SEARCH

The UPR is a complex signal transduction pathway that is initiated by the activation of at least three UPR stress sensors: inositol-requiring protein 1 (IRE1), ...