Circadian oscillations persist in low malignancy breast cancer cells

PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to ...

Here, we characterized the consequences of the daily oscillations of the clock-related gene PER2 in esophageal cancer cells and found that ...

Circadian tumor infiltration and function of CD8+ T cells dictate ...

Here, we show in murine and human cancers that these parameters exhibit circadian oscillations, driven by both the endogenous circadian clock of leukocytes and ...

Major roles of the circadian clock in cancer

In addition, abnormal biological rhythms promote the malignant progression of tumors by weakening the body's immunity. Immunity is an important ...

The emerging neuro-immune link connecting depression to cancer

In summary, cancers disrupt genetic circadian rhythms in gene expression and physiologic rhythms in immune and endocrine oscillations. Cancer chemotherapy is ...

The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell ...

Loss of Bmal1 or circadian photoperiod increases tumor initiation. In the intestinal epithelium the clock regulates transcripts involved in ...

Cancer clocks in tumourigenesis: the p53 pathway and beyond in

Epidemiologic studies have implicated circadian disruption in the development of breast and other cancers, and numerous clock genes are ...

Hypermetabolic state is associated with circadian rhythm disruption ...

We demonstrate how metabolic activity in cancer impacts circadian rhythms. In a mouse model of pancreatic adenocarcinoma, hypermetabolism disrupts circadian ...

MYC disrupts transcriptional and metabolic circadian oscillations in ...

Dysfunctional circadian rhythms are associated with pathologies including cancer. The oncogene MYC, which is frequently altered in human cancers, interferes ...

Disrupted Circadian Rhythms and Cancer (Chapter 14)

Of particular complexity remains the contribution of the circadian clock in individual cells during the process of transformation (cancer ...

Circadian clock, carcinogenesis, chronochemotherapy connections

Similarly, genetically engineered mice with clock disruption do not exhibit spontaneous or radiation-induced cancers at higher incidence than ...

Circadian rhythm and its role in malignancy

Aberrant expression of circadian clock genes could have important consequences on the transactivation of downstream targets that control the cell cycle and on ...

Circadian Oscillations of Clock Genes, Cytolytic Factors, and ...

Still, the underlying mechanisms governing NK cell circadian function are largely unknown. This uncertainty is not a trivial issue because alterations in ...

Research - Colby Computer Science

... Circadian Oscillations Persist in Low Malignancy Breast Cancer Cells, Cell Cyle, 2019. (* indicates senior authorship). H-H Lin, M Qraitem,Y Lian,SR Taylor ...

Extracellular Acidosis Promotes Metastatic Potency via Decrease of ...

Disrupted circadian rhythms are associated with a number of diseases, including cancer [10,11]. The cancer tissue has been shown to have lower expression of ...

Circadian clock and oral cancer (Review) - Spandidos Publications

Cancer-related genes like c-myc and p53 exhibit a circadian rhythm in vivo (3,4). Oncogenic activity such as excessive cell proliferation, loss ...

Disrupting the circadian clock: Gene-specific effects on aging ...

Conversely, in experimental models, overexpression of clock genes in tumors or in cancer cell lines reduces tumor growth [11, 42-45]. Mice homozygous for ...

Evaluating Circadian Oscillators in Cancer Stem Cells

Circadian rhythms are approximately 24-hour oscillations in physiology or behavior that are reported to be either poorly defined or lacking in cancer cells.

Loss of circadian clock gene expression is associated with tumor ...

In conclusion, loss of clock genes is associated with worse prognosis in breast cancer. Coordinated co-expression of clock genes, indicative of a functional ...

Impact of Circadian Rhythms on the Development and Clinical ...

Melatonin has also been a potent, safe, and low-cost therapeutic in cancer research (103). A randomized controlled trial of solid tumors found ...

Time-of-day specificity of anticancer drugs may be mediated by ...

In high- to low-throughput analysis using control or clock-deficient tumor cells, we found that several anticancer drugs exhibit rhythmic ...