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Cisplatin|Associated Nephrotoxic Effects in Children


Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto

The use of the effective antineoplastic agent cisplatin is limited by its serious side effects, such as oto- and nephrotoxicity. Ototoxicity is a problem of ...

Cisplatin-induced nephrotoxicity in childhood cancer - Europe PMC

Various definitions used to describe cisplatin nephrotoxicity potentially lead to differences in determination of risk factors. This study ...

Dose-related nephrotoxicity of carboplatin in children - Nature

Glomerular and proximal renal tubular function were investigated before and up to 2 years after treatment in 23 children who received ...

Cisplatin Nephrotoxicity in Children Treated for Cancer - ProQuest

Cisplatin, a chemotherapy commonly used to treat pediatric solid tumours, causes acute kidney injury (AKI) and may lead to chronic kidney disease (CKD) and ...

Mechanisms of Cisplatin Nephrotoxicity - MDPI

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity.

Management of Medication Toxicity or Intolerance: Nephrotoxic Effects

Tenofovir-associated nephrotoxicity in children with perinatally-acquired HIV infection: a single-centre cohort study. Clin Drug Investig. 2015;35(5):327-333.

Hypertension in long-term childhood cancer survivors after treatment ...

Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer. ... Long-term evaluation of. Ifosfamide-related ...

The identification of dual protective agents against cisplatin-induced ...

Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this ...

Molecular mechanisms of cisplatin-induced nephrotoxicity

However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to ...

Late Kidney Effects of Childhood Cancer and Cancer Therapies

Treatment of childhood cancer is associated with long-term risk of kidney disease and hypertension. With improving treatment regimens for childhood cancers, and ...

Chart Review of Predisposing Factors to Cisplatin-Induced ...

Cisplatin-induced nephrotoxicity is a major dose-limiting adverse event associated with the drug that can occur despite preventive measures. According to Miller ...

Nephrotoxicity Induced by Cancer Chemotherapy With Special ...

Mitomycin-associated renal failure frequently presents with signs of microangiopathic hemolytic anemia; renal failure is usually delayed but occasionally, it ...

Cisplatin-induced Nephrotoxicty and its Predisposing Factors for ...

BACKGROUND: Cisplatin-induced nephrotoxicity is the most common and devastating side effects which affects long-term outcome.

Protective Effect of Mannitol on Cisplatin-Induced Nephrotoxicity

Introduction: Cisplatin, a chemotherapeutic drug, is widely used for the treatment of various malignant tumors with good effects. However, ...

Kidney problems | Canadian Cancer Society

Sometimes kidney problems happen as a late effect of treatments for cancer during childhood ... cisplatin; carboplatin (Paraplatin, Paraplatin AQ) ...

Macrophage depletion protects against cisplatin-induced ototoxicity ...

Cisplatin therapy is associated with notable side effects, including ototoxicity, nephrotoxicity, and myelosuppression, which can be dose- ...

Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients ...

Nephrotoxicity is a major side effect of cisplatin that limits dosing and, therefore, the antitumor effect. Cisplatin accumulates in renal proximal tubular ...

Hydration Methods for Cisplatin Containing Chemotherapy

Cisplatin-induced nephrotoxicity (CIN) can be prevented by fluid hydration, electrolyte supplementation, or forced diuresis; however, ...

Risk factors for cisplatin‐induced long‐term nephrotoxicity in ...

Although CPL-induced long-term nephrotoxicity was found in half of the pediatric CS of solid tumors, clinically significant nephrotoxicity was ...

The Effect of Vitamin E on Cisplatin Induced Nephrotoxicity

Key Words: Cisplatin, Children, Nephrotoxicity, Vitamin E. *Please cite this article as: Nasiri M, Farhangi H, Badiee Z, Ghasemi A ...