Critical Role for TNF in the Induction of Human Antigen|Specific ...

TNF plays a crucial role in inflammation by signaling via T cell TNFR2

TNF itself induced TNFR2-dependent differentiation to Th17 cells (ROR-γt+IL-17Alo) with high levels of inflammatory gene expression (e.g., Csf2, ...

Distinct and Nonredundant In Vivo Functions of TNF Produced by T ...

Additionally, both T-cell-derived TNF and macrophage-derived TNF had critical and nonredundant functions in the promotion of autoimmune hepatitis. Our data ...

Tumor necrosis factor receptor 2-dependent homeostasis of ...

Treatment of tumor-bearing mice with recombinant human TNF resulted in a significant increase in tumor burden and metastatic foci. This correlated with an ...

Neutrophils and macrophages drive TNF-induced lethality via TRIF ...

Our findings suggest that in addition to their crucial role in TNF production, myeloid cells are central to TNF toxicity and position TRIF and ...

Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US

They are crucial for coordinating cell mediated immune response and play a critical role in modulating the immune system. Pro-inflammatory cytokines ...

Induction of cell death by tumour necrosis factor (TNF) receptor 2 ...

Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF‐R2, CD40 and CD30 are mediated by endogenous production of TNF.

Reprogramming of host energy metabolism mediated by the TNF ...

Together, our findings reveal that TNF-iNOS-HIF-1α-induced glycolysis in monocytes plays a critical role in host defense and sickness behavior ...

Anti-TNF therapy in IBD exerts its therapeutic effect through ... - Gut

Using cell type-specific IL-10 receptor mutant mice, we found that IL-10 signalling in macrophages but not T cells was critical for the induction of CD206+ ...

Early Response Cytokines and Innate Immunity

Tumor necrosis factor α (TNF-α)-induced cell adhesion to human endothelial cells is ... Critical role of 55-kilodalton TNF receptor in TNF-induced adhesion ...

TRAF6 deficiency promotes TNF-induced cell death through ...

TNF receptor-associated factor 6 (TRAF6) plays a key role in the regulation of innate immune responses by mediating signals from both TNF ...

Role of TNF-α and extracellular ATP in THP-1 cell activation ...

While recombinant human TNF-α augmented CD54 and CD40 expression in a dose-dependent manner, rhTNF-α did not increase CD86 expression. Furthermore, ...

Evidence that TNF-β (lymphotoxin α) can activate the inflammatory ...

Inflammatory cytokines play a key role in the pathogenesis of joint diseases such as rheumatoid arthritis (RA).

Recombinant Human TNF-alpha Protein 210-TA-005 - R&D Systems

It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism (1, 2). Human TNF-alpha ...

An Essential Role for TNF in Modulating Thresholds for Survival ...

Both peptide activation and ensuing Ag-induced apoptosis are quantitatively reduced in TNF−/− CD8 T cells. The latter observations can be related to decreased ...

TNF - Tumor necrosis factor - Homo sapiens (Human) | UniProtKB

Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis ...

may play a critical role in mediating signals for differentia- ... The high level of expression of TRANCE-R on DCs suggests a specific role for TRANCE in T cell– ...

Tumor necrosis factor α (TNF-α) receptor-II is required for TNF-α ...

Using receptor-specific agonistic antibodies or TNF-α mutants, previous studies in human ECs have demonstrated that p55, not p75, is critical ...

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate ...

Using cell-specific genetic deletion models, we identified an essential role for CX3CR1+MNP-derived TL1A in driving group 3 innate lymphoid cell ...

TNF activates calcium–nuclear factor of activated T cells (NFAT)c1 ...

First, we examined the effects of TNF on NFATc1 expression in human macrophages. TNF induced a transient and moderate increase in NFATc1 mRNA levels after 3 h ...

Critical Role of TNF-α-Induced Macrophage VEGF and iNOS ... - IOVS

A proinflammatory cytokine, tumor necrosis factor-α (TNF-α), is produced by a variety of cell types, including neutrophils, macrophages, lymphocytes, and ...