Crystal structure of dihydropyrimidine dehydrogenase

Dihydropyrimidine dehydrogenase [NADP(+)] | DrugBank Online

Details · 1.3.1.2 · DHPDHase · Dihydrothymine dehydrogenase · Dihydrouracil dehydrogenase · DPD.

dihydropyrimidine dehydrogenase | Nucleotide turnover

The IUPHAR/BPS Guide to Pharmacology. dihydropyrimidine dehydrogenase - Nucleotide turnover. Detailed annotation on the structure, function, physiology, ...

The Interaction of Porcine Dihydropyrimidine Dehydrogenase with ...

Indeed, Class 1 dihydroorotate dehydrogenases catalyze ostensibly the same chemistry using such a mechanism 4-6. X-ray crystal structures of DPD reveal a ...

Structural Organization of the Human Dihydropyrimidine ...

molecular defects (point mutations, deletions due to exon skipping) that were suggested as a potential molecular basis for DPD deficiency, even.

Force field parameters for Fe2+4S2-4 clusters of dihydropyrimidine ...

The dimeric dihydropyrimidine dehydrogenase (DPD) metalloenzyme, an adjunct anti-cancer drug target contains highly specialized 4 × Fe2+4S2-4 ...

Novel disease-causing mutations in the dihydropyrimidine ...

Analysis of the crystal structure of pig DPD suggested that five out of eight amino acid exchanges present in these patients with a complete DPD deficiency, ...

Identification of three novel mutations in the dihydropyrimidine ...

Analyses of the three-dimensional protein structure ofpig DPD showed that E244 belongs to thea5 helix ofthe FAD-binding domain II, which is ...

Mammalian dihydropyrimidine dehydrogenase: Added mechanistic ...

Dobritzsch, Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. · Schnackerz, Dihydropyrimidine ...

612779 - DIHYDROPYRIMIDINE DEHYDROGENASE; DPYD - OMIM

The DPYD gene encodes dihydropyrimidine dehydrogenase (EC 1.3.1.2), the initial and rate-limiting enzyme in the catabolism of the pyrimidine bases uracil and ...

Search by PDB author - Protein Data Bank Japan

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and ...

Dihydropyrimidine Dehydrogenase Deficiency, a Pharmacogenetic ...

Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of ... dihydropyrimidine dehydrogenase gene interpreted by analysis of the three- ...

POLYMORPHISM OF DIHYDROPYRIMIDINE DEHYDROGENASE ...

... dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure. ... Crystal structure of dihydropyrimidine dehydrogenase, ...

Escherichia coli Dihydropyrimidine Dehydrogenase Is a Novel NAD ...

The mammalian enzyme is composed of two identical subunits of approximately 111 kDa. Each subunit carries one FMN, one FAD cofactor, and four [4Fe/4S] clusters ...

Function and crystal structure of the dimeric P-loop ATPase CFD1 ...

A clinically relevant example is dihydropyrimidine dehydrogenase (DPYD) (51), an Fe-S enzyme catalyzing the reduction of pyrimidines and ...

Correlation between dihydropyrimidine dehydrogenase and efficacy ...

Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the phar- macokinetics of the anti-cancer drug 5-fluo- rouracil. EMBO J 2001 ...

Force Field Parameters for Fe2+4S2−4 Clusters of ... - MDPI

The dimeric dihydropyrimidine dehydrogenase (DPD), metalloenzyme, an adjunct anti-cancer drug target, contains highly specialized 4 × Fe2+4S2−4 clusters per ...

Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil ...

Close-up views of the 3D crystal structure models of the C29R, Y304H, and F438V mutation sites are shown in Figures 6A–C, respectively. The R29 ...

Structure of Dihydroorotate Dehydrogenase B - Cell Press

Results: Crystal structures have been determined for DHODB and its product complex. The DHODB heterotetramer is composed of two closely interacting PyrDB-PyrK ...

Perturbing the Movement of Hydrogens to Delineate and ... - NSF PAR

Crystal structures of DPD-ligand complexes have revealed that NADPH binds adjacent to the FAD cofactor and that the pyrimidine substrates associate within the ...

Functional Characterization of 21 Allelic Variants of ...

(F) The diagram of a fragment of the crystal structure of ... dihydropyrimidine dehydrogenase (DPD) variants for 5-fluorouracil metabolism.