Disclosing the role of XBP1s in Alzheimer's disease

The Biological Roles of XBP1 Isoforms in Pathophysiology - MDPI

Its aberrant expression is closely related to inflammation, neurodegenerative disease, viral infection, and is crucial for promoting tumor progression and drug ...

Emerging roles of ER stress in the etiology and pathogenesis of ...

XBP1s is considered as a prosurvival factor, upregulating genes involved in proteostasis control and secretory cell function. Since XBP1s can ...

Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD ...

To this end, we analysed the expression of the spliced form of XBP1 (XBP1s) in the different brain regions associated with each disease. In ...

Unfolded protein response IRE1/XBP1 signaling is required for ...

XBP1s gene delivery to aged mice can revert brain dysfunction at the morphological, electrophysiological, molecular, and behavioral level. •. Proteomic ...

Emerging roles of ER stress in the etiology and pathogenesis of ...

23 Cissé M, Duplan E & Checler F (2017) The transcription factor XBP1 in memory and cognition: implications in Alzheimer's disease. Mol Med 22, 905–. 917. 24 ...

Disclosing the role of XBP1s in Alzheimer's disease - AIR Unimi

Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer's disease. E. Marcello. Primo. 2023. Scheda breve; Scheda ...

XBP1 signalling is essential for alleviating mutant protein ... - PLOS

Finally, a polymorphism in the Xbp1 promoter is one of the risk factors for Alzheimer's disease [17] and the pathobiology of protein aggregation ...

Targeting the UPR transcription factor XBP1 protects against ...

XBP1-deficient mice were more resistant to developing disease features, associated with improved neuronal survival and motor performance, and a drastic decrease ...

UPR Responsive Genes Manf and Xbp1 in Stroke - Frontiers

The main function of the ER lumen is to maintain protein homeostasis, e.g., folding and quality control of secretory proteins, extracellular matrix proteins, ...

Essential Role of XBP1 in Maintaining Photoreceptor Synaptic ...

Conclusions: These findings suggest that XBP1 is a crucial regulator in maintaining synaptic integrity and retinal function, possibly through regulation of ...

Roles of XBP1s in Transcriptional Regulation of Target Genes - MDPI

Moreover, studies have shown that XBP1s regulates the transcription of diverse genes that are involved in lipid and glucose metabolism and immune responses.

Simple model systems reveal conserved mechanisms of Alzheimer's ...

Similar to other models, expression of AD-related proteins in flies results in aggregation and impaired cellular functions. Expressing hAPP in ...

New treatment reverses Alzheimer's disease signs, improves ...

A "chaperone" molecule that slows the formation of certain proteins reversed disease signs, including memory impairment, in a mouse model of ...

Unraveling the Role of RTP801 in Alzheimer's Disease

In the context of Alzheimer's disease (AD), higher levels of RTP801 can inhibit this complex, leading to problems in RNA splicing and the ...

Control of dopaminergic neuron survival by the unfolded protein ...

... reveal an important role ... Alzheimer's disease, Huntington disease, and ... XBP1 is crucial to the function of professional secretory cells, and ...

Constitutive Role for IRE1α-XBP1 Signaling Pathway in the Insulin ...

Overexpression of the activated XBP1 elevated the promoter activities of the sterol regulatory element-binding protein (SREBP)-1c and fatty acid synthase (FAS) ...

IRE1α–XBP1 signaling in leukocytes controls prostaglandin ...

IRE1α–XBP1 signaling mediates the rapid induction of pro-inflammatory cytokines in myeloid cells. This pathway has also been implicated in the ...

Medscape | Mol Ther - Publication Information - Medscape Education

Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer's disease. ... Alzheimer's disease by improving synaptic function and ...

Understanding the Role of Systemic Inflammation in Alzheimer's ...

Through each of these routes, systemic inflammation is believed to induce reactive, proinflammatory microglia and astrocytic phenotypes which ...

[PDF] Targeting the UPR transcription factor XBP1 protects against ...

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis · Medicine, Biology.