Disease heterogeneity and personalized prognosis in ...

Molecular Genetic Profile of Myelofibrosis: Implications in the ... - MDPI

... disease presentations, ultimately guiding personalized treatment plans for better outcomes with a chance for cures. Abstract. Myelofibrosis (MF) is an ...

evolving concepts in the management of polycythemia vera

Evolving concepts in patient management · Risk stratification · Recognizing the burden associated with disease · Defining end points for treatment.

Genomic Classification and Prognosis in Acute Myeloid Leukemia

In addition to class-defining lesions, other co-occurring driver mutations also had a substantial effect on overall survival. The prognostic ...

Analysis of genetic variants in myeloproliferative neoplasms using a ...

The 22 genes selected in this panel are known to be frequently mutated in myeloid neoplasms (not necessarily MPNs), and are known disease ...

Precision Medicine in BCR-ABL1 Negative Myeloproliferative ...

Risk stratification is a key tool for decision-making in any disease with markedly heterogeneous outcomes. In this regard, investigations of ...

Classification and Personalized Prognosis in Myeloproliferative ...

Genomic features were powerful predictors of myelofibrotic progression and leukemic transformation, although clinical disease features such as ...

Myelodysplastic Syndrome (MDS) - Medscape Reference

The heterogeneity of MDS reflects the fact that its course involves a series of cytogenetic events. In a subgroup of patients, the acquisition ...

Individualizing Care for Patients With Myeloproliferative Neoplasms

Although this model was based on the three driver mutations and some IPSS clinical parameters, the Mutation-Enhanced International Prognostic Scoring System ( ...

The genetic heterogeneity of hepatocellular carcinoma and the ...

Furthermore, the majority of patients have intermediate or advanced stage disease at diagnosis (2-5). ... heterogeneity poses for the practice of personalised ...

Longitudinal Cytokine Profiling Identifies GRO-α and EGF as

Numerous driver mutations have been identified but substantial disease heterogeneity remains unexplained, implying the involvement of additional as yet ...

Treating accelerated and blast phase myeloproliferative neoplasms

These advanced forms of disease are associated with poor prognosis with a median overall survival ... Classification and personalized prognosis in ...

Going Beyond Driver Mutations in Myeloproliferative Neoplasms

These findings emphasize the heterogeneity of triple-negative MPNs, as well as the possibility of hereditary MPN-like disorders in those with polyclonal ...

Clonal heterogeneity as a driver of disease variability in the ...

Hematopoietic stem cells (HSCs) are the suspected disease initiating cells and these cells must acquire a clonal advantage relative to non-mutant HSCs in order ...

Clonal heterogeneity as a driver of disease variability in the ...

Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are ...

What Role Does Genetics Play in Personalized Medicine? - Vial

GC is a heterogeneous disease ... The accurate and comprehensive molecular characterization of NSCLC can guide personalized treatment. Breast cancer.

The Temporal Sequence and the Differences in Somatic Mutation ...

Results: The somatic mutations in JAK2 influence the clinical behavior of the disease. We found that. ASXL1 or EZH2 mutation acquisition after JAK2 leads to PV,.

The Challenge of Tumor Heterogeneity in Personalized Medicine

Tools that facilitate accurate cancer diagnosis and support potential treatment, especially in the early stages of disease, can direct ...

Classification and Personalized Prognostic Assessment on the ...

... disease classification and prognosis. J Clin Oncol 39:1223-1233 ... heterogeneous disease. Finally, genomic features are rel- evant for ...

Acute Myeloid Leukemia Following Myeloproliferative Neoplasms

Survival and disease progression in essential ... Classification and personalized prognosis in myeloproliferative neoplasms.

Platelet Heterogeneity in Myeloproliferative Neoplasms

Megakaryocyte populations are expanded in patients with MPNs and are particularly central to disease pathogenesis in myelofibrosis. • The platelet transcriptome ...