Drugging The Undruggable Strategies And Future Directions

Understanding Undruggable Targets Challenges And Progress

We are discovering new ways of targeting oncogenes and degrading proteins, paving the way for an era of drug discovery where we can reach ...

Drugging the 'undruggable'. Therapeutic targeting of protein–DNA ...

To read the full-text of this research, you can request a copy directly from the authors. Citations (53) · References (211) ...

eBook: Unlocking Undruggable Targets - DrugBank Blog

The world of drug discovery is in a state of transformation, with advancements in biotechnology opening doors to new possibilities for ...

The Challenge of Drugging Undruggable Targets in Cancer

With the increasing realization of the importance of disrupting oncogenic protein-protein interaction, new challenges have emerged for classical ...

Cracking the Undruggable Code - October 22-24, 2024

Transforming Drug Discovery Research Together ... A significant portion of drug targets are classified as “undruggable”—meaning they lack typical binding sites, ...

Drugging an undruggable pocket on KRAS - PNAS

Despite decades of research, no approved drugs have been discovered for KRAS. ... This work demonstrates the druggability of this so-called switch ...

Drugging the Undruggable: Advances on RAS Targeting in Cancer

A comprehensive overview of the current landscape and future directions of ... strategies for overcoming drug resistance to specific mutations. Expand.

Drugging "undruggable" neurodegenerative disease targets with ...

... and envision future directions for small molecule drug discovery strategies to tackle "undruggable" neurodegenerative disease targets.

Full article: Developing Drugs for the 'Undruggable'

There are up to 650,000 'undruggable' protein-protein interactions (PPIs) in the human interactome that can be potentially considered as ...

Unlocking the Potential of Undruggable Targets in Drug Discovery

Overview · RAS Biology · Induced Proximity: The Future of Molecular Intervention · Deciphering Protein-Protein Interactions: Tools for the Intractable · RNA: A ...

Drugging the undruggable RAS: Mission Possible? - Semantic Scholar

Therapeutic targeting of RAS: New hope for drugging the "undruggable". · Medicine. Biochimica et biophysica acta. Molecular cell… · 2019.

Drug Design of “Undruggable” Targets - Wang - Wiley Online Library

Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more ...

Researchers discover new member of novel drug family for ...

Researchers discover new member of novel drug family for 'undruggable' targets ... Findings offer a roadmap for how to build compounds to target ...

Drugging the undruggable | Drug Discovery News

These innovations enhance research workflows and streamline drug discovery processes, while also representing a crucial step toward a more ...

Drugging the undruggable: how emerging modalities can offer new ...

For generations, the pharmaceutical industry has relied on small molecules as the basis for treatments of most illnesses and conditions. But with new ...

Drugging the 'undruggable' cancer targets - OUCI

Strategies to inhibit myc and their clinical applicability. Front. Cell Dev ... Peptide therapeutics: current status and future directions. Drug Discov ...

Drug resistance mechanisms and treatment strategies mediated by ...

The integration of USP inhibitors with current anti-cancer therapies offers a promising strategy to circumvent drug resistance. Therefore, this ...

Big data and artificial intelligence discover novel drugs targeting ...

Based on our previous research experience in artificial intelligence (AI)-assisted drug discovery, we review the above methods and successful cases to provide a ...

Induced protein degradation for therapeutics: past, present, and future

The concept of induced protein degradation by small molecules has emerged as a promising therapeutic strategy that is particularly effective in targeting ...

neurodegenerative disease targets with small molecules - SciEngine

Here we discuss recent progress and envision future directions for small molecule drug discovery strategies to tackle ''undruggable” neurodegenerative disease ...