Duplication of a germline promoter downstream of the IgH 3

Elucidation of IgH 3′ region regulatory role during class switch ...

In mature B cells, class switch recombination (CSR) replaces the expressed constant Cμ gene with a downstream CH gene.

Elucidation of the enigmatic IgD class-switch recombination via ...

Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region ... downstream of Cα, and ...

Comparison of Identical and Functional Igh Alleles Reveals a ...

Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. ... Genomic deletion of the whole IgH 3′ regulatory region ...

Genetic Instability and Transcriptional Regulation - IPBS-Toulouse

... Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination. Sci Rep 8, 9164. 2017. Braikia, F.Z. ...

Accessibility control and machinery of immunoglobulin class switch ...

IgH α enhancers are located ⬃16 Kb and 20 Kb downstream of the IgH Cα gene and in the mouse [36] and ... germline promoters and 3! Igα enhancers, to test the ...

Evolutive emergence and divergence of an Ig regulatory node

Duplication of a germline promoter downstream of the IgH 3' regulatory region impairs class switch recombination. Sci Rep (2018) 8(1):9164 ...

Germ‐line transcription occurs on both the functional and the ... - Scite

... germ-line transcription initiated from I promoters upstream ... IgH 3′ regulatory region-mediated activation of germline promoters and alters class switching.

Cis-Regulatory Elements and Epigenetic Changes Control Genomic ...

Similar promoter competition for the IgH 3. 0. RR has been observed between I ... Deletion of germline promoter PD beta. 1 from the TCR beta locus causes ...

Localization of the 3ⴕ IgH Locus Elements that Effect Long ... - CORE

germline transcription from I promoters of the target IgH ... of a homolog of the C␣3⬘/hs3 enhancer and of an allelic variant of the 3⬘ IgH/hs1,2 enhancer ...

Core enhancers of the 3′RR optimize IgH nuclear position and ...

Regarding CSR, the 3′RR entire deletion (Δ3′RR model) leads to a 2–5-fold decrease of IgH germline transcription (GLT) at S regions (6) and ...

Three-dimensional genome rewiring during the development of ...

Downstream of 3′RR are multiple ... Inducible CTCF insulator delays the IgH 3' regulatory region-mediated activation of germline promoters and ...

Three-dimensional genome rewiring during the development of ...

It was demonstrated that the promoters gain interactions with multiple non-coding regions at this late ... IgH germline transcription and ...

Genetically and Functionally Distinct Immunoglobulin Heavy Chain ...

In light of the IGH duplication, we asked whether E. ... The A-IGH and B-IGH germline loci differ notably in size, gene segment complexity, D.

Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar

Recently, it has been reported that the stickleback (Gasterosteus aculeatus) IgH locus contains three tandem duplicated Cτ, Cμ and Cδ genes ...

[전자책] Duplication of a germline promoter downstream of the IgH 3 ...

저자 : Joana M. Santos 저. 와이북스,학술전자출판협동조합. 판매가 1000원.

The IgH 3′ regulatory region controls somatic hypermutation in ...

E. . 2007 . Regulation of ε germline transcription and switch region mutations by IgH locus 3′ enhancers in transgenic mice .

... promoters is modulated by the IgH 3′RR located just downstream of the IgH locus (126). The 30 kb region of IgH 3′RR contains multiple DNase I hypersensitive ...

Copy Number Variation and Clinical Outcomes in Patients With ...

... germline CNVs from September 1, 2005, through January 3, 2018. Multicenter accrual occurred from community and academic medical centers ...

Characterizing short germline-specific promoters with a range of ...

... germline promoters using a single-copy gfp reporter assay in C. elegans. Six promoters resulted in ubiquitous expression, three did not drive detectable ...

DNA Replication Origins in Immunoglobulin Switch Regions ...

Transcription from the IgH Sα germline promoter occurs only upon activation. ... (E) Mutation analysis in the IgH Sμ region as in Figure 3B in activated ...