Endothelial Senescence

Metabolic regulation of endothelial senescence - Frontiers

The objective of this review is to provide an overview of the intricate interplay between cellular metabolism and senescence.

Endothelial cell senescence is associated with disrupted cell-cell ...

Replicative senescence affects the adherens junctions and, even more strongly, tight junctions, and compromises the integrity of the endothelial barrier.

Colchicine prevents oxidative stress-induced endothelial cell ...

The SASP factors released from senescent cells affect the function of the neighboring cells and induce senescence in them [10]. This paracrine ...

Endothelial Cell Senescence in the Pathogenesis of ... - IntechOpen

In this chapter, we examine the pathophysiological mechanism(s) involved in endothelial senescence, leading to CVD as well as the biochemical and cellular ...

Senescent endothelial cells promote liver metastasis of uveal ...

We found that endothelial cells exhibit significant senescence during the metastasis of uveal melanoma, which may be associated with liver metastasis of uveal ...

Endothelial cellular senescence is inhibited by liver X receptor ...

To conclude, activation of LXRs can prevent endothelial cellular senescence accelerated by hyperglycemia. This beneficial effect on endothelial cellular ...

Glomerular endothelial cell senescence drives age‐related kidney ...

AbstractThe mechanisms underlying the development of glomerular lesions during aging are largely unknown. It has been suggested that ...

Endothelial senescence and microRNA - De Gruyter

Cellular senescence occurs when cells lose the ability to divide and proliferate. Endothelial cell senescence is associated with vascular ...

[PDF] Endothelial Cell Senescence in the Pathogenesis of ...

New hypotheses supported by experimental results suggest that the senescent endothelial cell may induce a gen- eral process of vascular senescence, ...

Endothelial Cell Senescence Effect on the Blood-Brain Barrier in ...

Age is an important risk factor of stroke, cognitive decline, and dementia. Senescent endothelial cells (ECs) accumulate with advancing age ...

Mechanisms of endothelial senescence - The Physiological Society

The occurrence of endothelial cell senescence in the vasculature is gaining increasing recognition. Cell culture studies indicate that both cell ...

Senescence-Induced Oxidative Stress Causes Endothelial ...

Endothelial dysfunction is an early pathophysiological hallmark in the development of cardiovascular disease. Senescence, the cellular equivalent of aging, was.

Cellular Senescence in Endothelial Dysfunction - Fight Aging!

With aging, cells of the endothelium exhibit stress, inflammation, and altered behavior, contributing to the development of atherosclerosis and ...

Senescent endothelial cells: a potential target for diabetic retinopathy

This review focuses on the mechanisms of EC senescence in the pathogenesis of DR and summarizes the current research advances in strategies targeting SCs and ...

Oxidative Stress Induces Endothelial Cell Senescence via ...

Abstract. Accumulating evidence has shown that diabetes accelerates aging and endothelial cell senescence is involved in the pathogenesis of diabetic vascular ...

Vascular Endothelial Senescence - UNL Digital Commons

Emerging studies highlight that perturbation of endothelial cell. (EC) senescence is a potential link between inflammation and aging. Here, we ...

The matricellular protein TSP1 promotes human and mouse ...

Keeping endothelial cells young. Aging causes once-proliferating cells to undergo cell cycle arrest and become senescent, thus impairing tissue ...

Cellular and molecular biology of aging endothelial cells

Aging and endothelial dysfunction are risk factors for cardiovascular disease. Both oxidative stress and inflammation suppress endothelial function in older ...

Endothelial cell senescence is associated with disrupted cell-cell ...

Conclusions. Our findings show that the presence of senescent endothelial cells in a non-senescent monolayer disrupts tight junction morphology ...

Endothelial cell senescence exacerbates pulmonary hypertension ...

Senescent ECs overexpress Notch ligands. Thereby, senescent ECs activate Notch signaling in SMCs in a juxtacrine manner. Notch inhibition improves the worsened ...