Epidermal growth factor–stimulated Akt phosphorylation requires ...

Epidermal Growth Factor Stimulates Nuclear Factor-κB Activation ...

The EGF-induced ROS production was inhibited by DPI. Stimulation of cells with EGF resulted in an increase in Akt phosphorylation at Ser473, which was inhibited ...

EGFR-dependent tyrosine phosphorylation of integrin β4 is not ...

It activates multiple signaling pathways, including the PI3K/Akt and MAPK signaling pathways. Furthermore, in some cell types, EGF also ...

p38 kinase regulates epidermal growth factor receptor ...

Western blot analysis using an antibody against phospho‐Cbl confirmed that EGF's ability to stimulate Cbl phosphorylation was completely blocked by SB202190 ...

EGF receptor signaling, phosphorylation, ubiquitylation and ... - eLife

For the last four decades, EGFR, the receptor for epidermal growth factor (EGF), has been the predominant experimental model for studying the ...

Akt Binds to and Phosphorylates Phospholipase C-γ1 in Response ...

In this model, phosphorylation of PLC-γ1 Y783 by EGF causes the conformational change of PLC-γ1 to allow the interaction of its SH3 domain with Akt proline-rich ...

HER2 expression defines unique requirements for flotillin and c-Src ...

We found a selective requirement for flotillin and c-Src in EGF-stimulated activation of EGFR signaling leading to Akt phosphorylation in cells ...

Scalaradial Inhibition of Epidermal Growth Factor Receptor

mal growth factor (EGF)-stimulated Akt phosphorylation, which is required for Akt activation. SLD also blocked the EGF-stim- ulated membrane translocation ...

Epidermal Growth Factor (EGF) Autocrine Activation of Human ...

Thrombin stimulation induced phosphorylation of the serine/threonine kinase AKT at threonine 308, and this required EGFR tyrosine kinase activity because ...

Epidermal Growth Factor Receptor–Mediated Proliferation of ...

Finally, Cyclin D1/Cdk interaction was evaluated by immunoprecipitation. Results: EGFR activation in intestinal epithelial cells induced the expression of p21 ...

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway ...

Moreover, prolonged inhibition of EGF signaling by EGFR tyrosine kinase inhibitors results in spontaneous reactivation of AKT without a ...

Estrogen Negatively Regulates Epidermal Growth Factor (EGF ...

Breast cancer cell growth may be stimulated by 17β-estradiol (E2) or growth factors like epidermal growth factor (EGF). However, tumors typically depend on only ...

Phosphatidylinositol 3-Kinase Is Required for Growth Factor ...

We also found that transforming growth factor-β stimulated PI3K activity and the phosphorylation of Akt, a downstream signaling molecule of PI3K ...

A comprehensive pathway map of epidermal growth factor receptor ...

Gab1 also binds to activated EGFR either directly or via Grb2 bound to activated EGFR, and is phosphorylated on its tyrosine 446, 472, and 589. (B) The same ...

Expression of ErbB2 renders EGF-stimulated Akt phosphorylation...

The epidermal growth factor (EGF) receptor (EGFR) controls many aspects of cell physiology. EGF binding to EGFR elicits the membrane recruitment and activation ...

Emerging functions of the EGFR in cancer - Sigismund - FEBS Press

In response to EGF stimulation, the EGFR controls expression of hexokinase (HK1) and phosphorylation of the pyruvate kinase M2 (PKM2), two ...

Galpha(i1) and Galpha(i3) are required for epidermal growth factor ...

The precise mechanism whereby epidermal growth factor (EGF) activates the serine-threonine kinase Akt and the mammalian target of rapamycin (mTOR) complex 1 ...

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(D) Erlotinib and gefitinib inhibit EGFR, but not Akt phosphorylation, in MDA-MB-231 cells. ... (K) Gefitinib-induced autophagy requires Sec5, but ...

The Specificity of EGF-Stimulated IQGAP1 Scaffold ... - Nature

Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer.

Regulation of Signaling from the Epidermal Growth Factor Family

(5) The EGF receptors (EGFR) are controlled by interactions between family members and ligand stimulation, the activation of particular EGFR-family members ...

Akt-ing Up Just About Everywhere: Compartment-Specific ... - Frontiers

Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis. Mol. Biol. Cell 26, 3504–3519 doi: 10.1091 ...