Experts Debate Bolus vs Continuous Infusion 5|FU

5-FU induced cardiotoxicity: case series and review of the literature

5-FU was given as bolus at 400 mg/m2, followed by 1200 mg/m2/day continuous infusion over 46 h. Approximately 12 h into receiving the first ...

Risk of Overcorrection in Rapid Intermittent Bolus vs Slow ...

This randomized clinical trial compares the risk of overcorrection with use of rapid intermittent bolus and slow continuous infusion with ...

Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for ...

In the FL group, each cycle comprised a 2-hour infusion of 200 mg of leucovorin per square meter of body-surface area followed by a bolus of 400 mg of ...

5-fluorouracil and cardiotoxicity: a review - Sage Journals

Indeed, 5-FU is cleared rapidly from the bloodstream with a half life of 15–20 min, suggesting that continuous infusions would allow for drug accumulation or at ...

The Use of Leucovorin in Colorectal Cancer | Cancer Care Ontario

-There is no discussion regarding data on LV in the setting of deleting the bolus. ... and 5-FU, IV bolus, 1 hr after leucovorin infusion, weekly.

Phase II Study of a Weekly 8-Hour 5-Fluorouracil and Leucovorin ...

A weekly, 8-h 5-FU continuous infusion (CI) regimen may produce a dual effect, because it elicits both a high plasma 5-FU level and also a durable exposure to 5 ...

Successful 5-fluorouracil (5-FU) infusion re-challenge in a metastatic ...

Currently, expert consensus advises against re-challenge with 5-FU following cardiac toxicity, given risks of toxicity recurrence and nontrivial ...

Skipping 5-FU Bolus Enhances Chemo Tolerance in GI Cancers

Initial unadjusted analyses indicated that patients receiving the 5-FU bolus had longer overall survival than those who did not (20.3 vs 14 ...

Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton ...

In addition, intravenous proton pump inhibitor (PPI) therapy, given as a bolus followed by continuous infusion, is recommended in patients with active bleeding, ...

Continuous infusion fluorouracil/leucovorin and bolus mitomycinâ•'C ...

No effective systemic salvage therapy exists for patients with advanced colorectal cancer who progress after receiving bolus fluorouracil (FU) ...

Reproducibility of bolus versus continuous thermodilution for ...

CFRcont showed a higher reproducibility than CFRbolus (variability: 12.7±10.4% continuous vs 31.26±24.85% bolus; p<0.001). MRR showed a higher reproducibility ...

Safety of Cisplatin Combined with Continuous 5-FU versus Bolus 5 ...

i) Treatment A: The FP regimen consisted of 5-FU at a dose of 800 mg/m2/d in continuous infusion for 5 consecutive days and cisplatin at 100 mg/m2 in a 1- h ...

Gemcitabine with or without continuous infusion 5-FU in advanced ...

In a phase III trial, which compared 5-FU bolus with GEM, survival (18 vs 2% at 1 year) and clinical benefit response (24 and 4.4%) were ...

Continuous versus bolus intermittent loop diuretic infusion in acutely ...

Additionally, continuous infusion may induce an increased dieresis, reducing systemic and pulmonary congestion more efficaciously, thus avoiding ...

Pharmacokinetics of continuous transarterial infusion of 5 ...

... bolus and HAIC is administered via a prolonged, continuous infusion (8). Theoretically, the prolonged, high regional concentration of the ...

Phase 3 Study of Palonosetron IV Infusion Vs. IV Bolus for

PALO ¼ palonosetron. Vol. 60 No. 3 September 2020. 571. IV PALO Infusion Vs. Bolus for CINV Prevention. Page 5. cancer and pre-existing atrial ...

A Comparison of Continuous Infusion of Alteplase with Double ...

The rate of any stroke and the rate of hemorrhagic stroke with the double-bolus regimen were 1.92 percent and 1.12 percent, as compared with ...

Efficacy of Intravenous Infusion of Fluorouracil Compared with Bolus ...

... Therefore, multiple bolus injections or continuous infusion are required to maintain 5-FU concentrations at an effective level throughout the treatment ...

Continuous Infusion Versus Bolus Injection of Loop Diuretics for ...

Several studies have shown that continuous infusion was associated with lesser adverse effects and short hospital stay compared to bolus ...

Effects of Bolus Injection of 5-Fluorouracil on Steady-State Plasma ...

concentration was also determined at 2 weeks to assess long-term exposure to 5-FU. ... ng/mL and 9.4 ng/mL in the patients with and without the ...