Genome|wide identification of transcriptional enhancers during ...

Identification of Transcribed Enhancers by Genome-Wide Chromatin ...

Recent work has shown that RNA polymerase II-mediated transcription at distal cis-regulatory elements serves as a mark of highly active enhancers.

Transcriptional enhancers: from prediction to functional assessment ...

... gene transcription. Unlike other genomic elements, enhancers are challenging to identify because they function independently of orientation, are often ...

Identification of genomic enhancers through spatial integration of ...

Cellular identity is defined by Gene Regulatory Networks (GRNs), in which transcription factors bind to enhancers and promoters to regulate target gene ...

Genome-wide identification of enhancers and transcription factors ...

Background Satellite cells are the myogenic precursor cells in adult skeletal muscle. The objective of this study was to identify enhancers ...

From prediction to functional assessment on a genome-wide scale

1093/hmg/ddg180. Levine, M. 2010. Transcriptional enhancers in animal develop- ... diator establish super-enhancers at key cell identity genes.

Enhanced Identification of Transcriptional Enhancers Provides ...

Cap analysis of gene expression. (CAGE) identifies transcribed enhan- cers at exceedingly high nucleotide resolution by detecting enhancer RNAs.

Identification and characterization of transcriptional enhancers in the ...

Author(s): Heintzman, Nathaniel David | Abstract: This dissertation describes the use of high-throughput molecular biological techniques and bioinformatics ...

An encyclopedia of enhancer-gene regulatory interactions ... - bioRxiv

Abstract. Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the impact of human ...

Genome-wide analysis of histone marks identifying an epigenetic ...

Finally, to identify the transcription network within which the epigenetically regulated promoters and enhancers acted to govern gene expression in TAC ...

Transcriptional enhancers: from properties to genome-wide ...

Enhancers contain short DNA sequences, which are binding sites for transcription factors. In ... identification of enhancers on the basis of their activity.

Characterization of transcriptional enhancers in the chicken genome ...

In this study, we leveraged epigenetic data from the Functional Annotation of Animal Genomes project to identify promoter and putative enhancer regions.

Enhancer-promoter communication in Drosophila developmental ...

Enhancers play an essential role in gene regulation by receiving cues from transcription factors and relaying these signals to modulate ...

Genome-wide identification of enhancers in skeletal muscle

Our studies identified a role for MyoD1 in condition-specific enhancer assembly through recruitment of transcription factors and histone-modifying enzymes that ...

dna sequencing - How to find the enhancer region of a specific gene?

There are several ways to identify enhancers: (1) Chip seq / chip-chip recognize transcription factor binding sites, (2) Enhancer specific factors can also be ...

Evidence for additive and synergistic action of mammalian ... - eLife

Temporal changes in genome-wide enhancer transcription activity during a transdifferentiation event reveal additive and synergistic enhancer ...

Transcribed enhancers lead waves of coordinated transcription in ...

used cap analysis of gene expression (CAGE) to analyze gene enhancer and promoter activities in a number of human and mouse cell types. The RNA of enhancers was ...

Genetic Variation in Enhancers Modifies Cardiomyopathy Gene ...

... enhancer regions identified in the MYH7 and LMNA gene ... Active Cardiac Enhancers Harbor Genetic Variants in Transcription Factor Binding Sites.

ReFeaFi: Genome-wide prediction of regulatory elements driving ...

Regulatory elements control gene expression through transcription initiation (promoters) and by enhancing transcription at distant regions (enhancers).

Functional genomic approaches to elucidate the role of enhancers ...

While ChIP-seq methods to identify TF binding have certainly advanced our ability to locate putative cis-regulatory elements in the genome, ...

Plant Enhancers: A Call for Discovery

the genome-wide identification of enhancers in a high-throughput manner. ... analysis reveals intrinsic bias in transcription factor footprint.