- Germline EGFR Mutations and Familial Lung Cancer🔍
- Would you send a lung cancer patient for genetic🔍
- Familial rare EGFR|mutant lung cancer syndrome🔍
- Novel EGFR V834L Germline Mutation Associated With Familial ...🔍
- Identification of the Unique Clinical and Genetic Features ...🔍
- Presentation of EGFR mutations in 162 family probands with ...🔍
- Germline Mutation of T790M and Dual/Multiple EGFR Mutations in ...🔍
- Germline mutations causing familial lung cancer🔍
Germline EGFR mutations and familial lung cancer
Germline EGFR Mutations and Familial Lung Cancer | Request PDF
Somatic testing of lung cancers in carriers revealed that 35 of 37 (95%) had an EGFR driver co-mutation. Among 36 germline carriers without a ...
Germline EGFR Mutations and Familial Lung Cancer
Somatic testing of lung cancers in carriers revealed that 35 of 37 (95%) had an EGFR driver comutation. Among 36 germline carriers without a ...
Would you send a lung cancer patient for genetic - theMednet
EGFR T790M mutations can indeed be present in the germline and represent a heritable risk factor for lung cancer. The two families I have identified were ...
Familial rare EGFR-mutant lung cancer syndrome - BINASSS
Conclusion: Although rare, germline p.R776H EGFR lung cancer mutations are over-represented in light or never smoking female patients who often ...
Novel EGFR V834L Germline Mutation Associated With Familial ...
A case study of a patient with a targetable somatic EGFR mutation and a novel EGFR germline variant, which also occurred in other family members with lung ...
Identification of the Unique Clinical and Genetic Features ... - Frontiers
However, the frequency of EGFR T790M germline mutation in Chinese lung cancer patients was 0.0078%, suggesting a distinct germline mutation ...
Presentation of EGFR mutations in 162 family probands with ...
Several other studies reported the existence of the EGFR-T790M germline mutation in familial MPLC cases (14,15). Our previous study also revealed that the EGFR- ...
Germline Mutation of T790M and Dual/Multiple EGFR Mutations in ...
We report a confirmed case of germline EGFR T790M mutation and a case series of dual/multiple EGFR mutations in patients with lung adenocarcinoma.
Germline mutations causing familial lung cancer - Nature
R1075L mutation is causative for the familial lung cancer in this study, with CENPE, CACNB2 and LCT as second-place candidates. All have ...
Potential genetic modifiers for somatic EGFR mutation in lung cancer
Familial lung cancers more likely have concurrent EGFR mutations along with mutations in their germline cancer predisposition genes including ...
Germline EGFR mutations in lung cancer (Review) - OUCI
List of references · Mäkinen, Genomic evolution in a patient with lung adenocarcinoma with a germline EGFR T790M mutation, JTO Clin Res Rep, № 2, с. 100146 · van ...
Germline EGFR R776H mutation | OTT - Dove Medical Press
Lung cancer is a major cause of death from cancer in the world. Genetic alterations are risk factors for lung cancer development, especially ...
EGFR-Mutant Lung Cancer: What You Need to Know | Dana-Farber
EGFR mutations usually occur during the patient's lifetime, although in a small number of cases the EGFR mutation can be inherited from a parent ...
Germline EGFR mutations in lung cancer (Review) - ResearchGate
Epidermal growth factor receptor (EGFR) mutations are important events in carcinogenesis. The present study summarized the common germline mutations of EGFR, ...
Higher frequency but random distribution of EGFR mutation ...
Although univariate analysis suggested a higher EGFR mutation rate among patients with lung cancer family history, the demographics between each ...
Germline ERBB3 mutation in familial non-small-cell lung carcinoma
Rarely, dominantly inherited non-small-cell lung cancer (NSCLC) has been reported due to somatic mutations in EGFR/ErbB1 and ERBB2. Germline exome sequencing ...
Novel EGFR V834L Germline Mutation Associated With Familial ...
Family-related lung cancer has been reported occasionally, but little is known about the genetic backgrounds. With routine analysis for targetable mutations, ...
Genomic Evolution in a Patient With Lung Adenocarcinoma With a ...
EGFR germline variants are rare; germline T790M mutations have an estimated prevalence of 0.1% among patients with lung cancer and 0.003% in the ...
Two cases of non-small cell lung cancer patients with somatic or ...
However, only few germline EGFR mutations have been reported, and their association with NSCLC familial risk remains ambiguous. Here, we report ...
Inherited lung cancer: a review | ecancer
In various studies, Sanger sequencing has correlated familial clustering of lung cancer with a germline T790M mutation in EGFR [49–56]. This ...