High interstitial fluid pressure — an obstacle in cancer therapy

Interstitial Fluid Pressure in Tumors: Therapeutic Barrier and ...

... 1 The efficacy of systemic cancer therapies is limited by poor drug penetration in tumor tissue. 2 The major obstacle for tissue penetration ...

Interstitial fluid pressure in tumors: therapeutic barrier and biomarker ...

... interstitial fluid pressure. Reductions in interstitial fluid pressure ... High interstitial fluid pressure — an obstacle in cancer therapy · C. HeldinK ...

Interstitial Fluid Pressure and Vascularity of Intradermal and ...

High interstitial fluid pressure (IFP) in tumors has been shown to be associated with poor prognosis. Mechanisms underlying the intertumor heterogeneity in IFP ...

Tumor Interstitial Fluid as Modulator of Cancer Inflammation ...

TIF and its pressure have been implicated as an important factor that impairs the delivery of chemotherapy and cell therapy to tumors and may influence the ...

Measurement of Tumor Pressure and Strategies of Imaging Tumor ...

Most strikingly, tumor-associated abundant ECM increases the interstitial fluid pressure (IFP) compared with that of a normal tissue. High-IFP ...

Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is ...

Elevated interstitial fluid pressure can present a substantial barrier to drug delivery in solid tumors. This is particularly true of pancreatic ductal ...

Curvature-mediated rapid extravasation and penetration of ... - PNAS

Elevated interstitial fluid pressure (IFP) within pathological tissues (e.g., tumors, obstructed kidneys, and cirrhotic livers) creates a significant hindrance ...

High Interstitial Fluid Pressure Is Associated with Tumor-Line ... - PLOS

High IFP has been associated with low radiocurability and high metastatic frequency in human melanoma xenografts and with poor survival after radiation therapy ...

High tumor interstitial fluid pressure identifies cervical cancer ...

19Heldin CH, Rubin K, Pietras K, et al. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer 2004; 4: 806–13. 20 ...

Not only tumor but also therapy heterogeneity - Annals of Oncology

10. Heldin, C.-H. ∙ Rubin, K. ∙ Pietras, K. ... High interstitial fluid pressure – an obstacle in cancer therapy. Nat Rev Cancer. 2004; 4:806-813. Crossref.

Radiation Therapy Modulates Tumor Physical Characteristics to ...

High intratumoral pressure, caused by tumor cell-to-cell interactions, interstitial fluid pressure, and surrounding stromal composition, ...

Interstitial fluid pressure, vascularity and metastasis in ectopic ...

Abstract Background High tumour interstitial fluid pressure (IFP) has been adversely linked to poor drug uptake in patients, and to treatment response ...

Targeting the invincible barrier for drug delivery in solid cancers

... tumor microenvironment that causes the high interstitial fluid pressure ... High interstitial fluid pressure - an obstacle in cancer therapy.

Longitudinal Monitoring of Simulated Interstitial Fluid Pressure for ...

Solid stress can directly compress cancer, and stromal cells, whereas the blood and lymphatic vessels are indirectly compressed, inhibiting and driving tumor ...

REVIEWS

High interstitial fluid pressure — an obstacle in cancer therapy. Nature Rev. Cancer 4, 806–813 (2004). An excellent review of IFP in cancer. 17. Netti ...

Review Article Strategies to improve drug distribution in solid tumor

Cancer 1998; 82: 2418-2426. [8] Heldin CH, Rubin K, Pietras K and Ostman A. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer ...

Effect of Ultrasound Combined With Microbubble Therapy ... - Frontiers

Interstitial fluid pressure (IFP) in tumor tissue is significantly higher than that in normal tissue, which reduces the effectiveness of ...

Tumor Interstitial Fluid as Modulator of Cancer Inflammation ...

For almost 30 years. TIF remained a neglected entity until it was demonstrated that TIF, and in particular its high pressure, constitutes an important obstacle ...

Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma

High interstitial fluid pressure—an obstacle in cancer therapy. Nat Rev ... Interstitial pressure-gradients in tissue-isolated and subcutaneous tumors— ...

Predicting intratumoral fluid pressure and liposome accumulation ...

The EPR effect has motivated the clinical use of nano-therapeutics, with mixed results on treatment outcome. High interstitial fluid pressure ( ...