IRE1/XBP1 and endoplasmic reticulum signaling

[PDF] The IRE1/XBP1 signaling axis promotes skeletal muscle ...

This study has identified a novel signaling axis that link ER stress-induced non-myogenic signaling pathway to myoblast fusion and demonstrates that the ...

Targeting endoplasmic reticulum stress signaling in ovarian cancer ...

Subsequently, 3 primary UPR signaling pathways, orchestrated by inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), ...

Exploring the IRE1 interactome: From canonical signaling functions ...

This interaction connects the UPR and Ca2+ metabolism, where STIM1 promotes XBP1 mRNA splicing upon ER Ca2+ store depletion and IRE1 promotes STIM1-dependent ER ...

Endoplasmic reticulum stress response in coronavirus infection ...

The IRE1 RNase domain is involved in unconventional splicing of XBP1, creating XBP1S which induces expression of protein folding genes. The RNase domain can ...

Targeting IRE1 endoribonuclease activity alleviates cardiovascular ...

... ER stress signature genes, including IRE1/XBP1 target genes. ... Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases.

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein ...

proteins, Ire1, PERK, and ATF6, activate signaling in each UPR branch. Upon activation, each sensor elicits unique downstream responses. Ire1's cytosolic RNase ...

The requirement of IRE1 and XBP1 in resolving physiological stress ...

IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress. In cultured ...

Unfolded protein response IRE1/XBP1 signaling is required for ...

We report that genetic disruption of the ER stress sensor IRE1 accelerated age‐related cognitive decline.

QUANTITATIVE MEASUREMENT OF SPLICED XBP1 mRNA AS AN ...

It is thus thought to be an important marker reflecting both IRE1 and ATF6 signaling in response to ER stress. For quantitative measurement of XBP1 gene ...

Dual RNase activity of IRE1 as a target for anticancer therapies

... PERK luminal domain tetramerization in endoplasmic reticulum stress signaling. ... IRE1/XBP1s activation confers targeted ER proteostasis ...

Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T ...

The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of ...

The unfolded protein response components IRE1α and XBP1 ...

... XBP1 endoplasmic reticulum stress pathway in human lung-derived cells. ... Pharmacologic IRE1/xbp1s activation confers targeted ER ...

A little ER stress isn't bad: the IRE1α/XBP1 pathway shapes ILC3 ...

These results advance our understanding in the use of ILCs as biomarkers not only to predict disease outcomes but also to indicate the response ...

IRE1-mediated unconventional mRNA splicing and ... - Genes Dev

(8) The two pathways signal- ing through the ER stress sensors IRE1 and ATF6 merge through qualitative and quantitative regulation of XBP1 to activate the UPR.

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 ...

RIDD targets could possibly impact on the splicing of XBP1 mRNA, thus fine-tuning the response to ER stress and impacting on subsequent cell ...

CHOP and IRE1α-XBP1/JNK signaling promote Newcastle Disease ...

In this report, we revealed the mechanisms underlying NDV-induced apoptosis via investigation of endoplasmic reticulum (ER) stress-related ...

Cartilage-specific ablation of XBP1 signaling in mouse results in a ...

IRE1 signaling in cartilage development in vivo has not been investigated. IRE1 activation by ER stress results in the unconventional splicing of XBP1 mRNA ...

IRE1-mediated unfolded protein response Gene Ontology Term (GO ...

... endoplasmic reticulum stress | IRE1 signal transduction pathway | UPR signaling by IRE1 stress sensor ... IRE1 is the transcription factor HAC1 in yeast, or XBP1 ...

QuickGO::Term GO:0036498

One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 ... IRE1 signaling in response to endoplasmic reticulum stress, related.

Xbp1-Independent Ire1 Signaling Is Required for Photoreceptor ...

Introduction. The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane proteins are synthesized and folded. When the ...