Identification and functional characterization of imatinib‐sensitive ...

Proteomic Characterization Identifies Clinically Relevant Subgroups ...

This study highlights the importance of SQSTM1 in reducing gastrointestinal stromal tumor imatinib sensitivity, which might improve the clinical ...

Engineering and Functional Characterization of Fusion Genes ...

Treatment of Ba/F3 cells addicted to BCR-ABL1 and EML4-ALK exhibited robust sensitivity to ABL inhibitor imatinib (IC50 ¼ 0.3012 mmol/L) and ALK inhibitor ...

Identification of fusion genes and characterization of transcriptome ...

A number of new genetic aberrations were identified using integrated transcriptome and genomic analysis. Distinct T-ALL subgroups were defined ...

Deciphering the mechanism of Indirubin and its derivatives in the ...

Imatinib resistance related genes ... After gene chip data analysis, we obtained a heat map of the differentially expressed genes of the gene chip ...

Corneal Infantile Myofibromatosis Caused by Novel Activating ...

Imatinib was first identified as a small-molecule inhibitor of the protein tyrosine kinase BCR-ABL, which constitutes of a fusion of ABL1 located on chromosome ...

Functional characterization of the common c.-32-13T>G mutation of ...

Therefore, we decided to further investigate this issue using the more sensitive western blot assay. ... Identification of eight novel mutations of the ...

Comparative gene expression profile of chronic myeloid leukemia ...

We detected differential expression of 39 genes that correlate with the imatinib-resistant phenotype. The resistant cells overexpress several genes associated ...

Imatinib: Uses, Interactions, Mechanism of Action | DrugBank Online

Imatinib is indicated for the treatment of adult and pediatric chronic myeloid leukemia with Philadelphia chromosome mutation (Ph+) in blast crisis, accelerated ...

Role of pharmacogenetics in personalised imatinib dosing - Barratt

In the CML setting, treatment outcomes correlate with plasma imatinib concentrations, which show large interpatient variability. Treatment outcomes also ...

RP11-616M22.7 recapitulates imatinib resistance in gastrointestinal ...

... characterization of the lncRNA landscape in GIST ... identified lncRNAs that possibly mediate the sensitivity of GIST patients to imatinib.

Molecular identification and functional characterization of rabbit ...

We found that rabbit (rb) MATE1 and rbMATE2-K both support the [H+]-sensitive transport of TEA, MPP, and cimetidine. Furthermore, whereas the two ...

Comparison of Hepatotoxicity Associated With New BCR-ABL ...

... Imatinib Among Patients With Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis ... The sensitivity analysis indicated that ...

GLEEVEC® (imatinib mesylate) tablets Label - accessdata.fda.gov

The analysis confirmed that exposure of imatinib in ... Patients that harbor the D816V mutation of c-Kit are not sensitive to Gleevec and should not receive ...

Chronic Myeloid Leukemia Patients Sensitive and Resistant to ...

Metabolic perturbation of CML after imatinib treatment. To facilitate the identification of the compounds that were affected by exposure to imatinib, three ...

Mutant KIT as imatinib-sensitive target in metastatic sinonasal ...

Molecularly guided treatment with imatinib in analogy to the management of gastrointestinal stromal tumor (GIST) resulted in a dramatic and durable response ...

Identification and characterization of essential genes in the human ...

Thus, the dependence on one paralog might reflect functional absence of the other paralog. Indeed, DNA sequencing of DDX3X in Raji cells ...

Molecular and functional characterization of a new 3′ end ... - ArTS

inhibited by Imatinib in a way similar to that observed for the Imatinib-sensitive ∆559 KIT control, whereas the kinase activity and thus receptor ...

Activity of imatinib in systemic mastocytosis with chronic basophilic ...

Our results identify a second case of the fusion and confirm the unusual breakpoint associated with this fusion. This work also illustrates the ...

Identification of Genes That Modulate Susceptibility to ...

Expanded mutant colony cells were treated with FA (0, 20, 40, 60, 80, 90, 100, or 120 μM) and imatinib (0, 0.1, 0.2, or 0.5 μM) for up to 96 h and cell ...

Screening and identification of key genes in imatinib-resistant ...

The enriched functions and pathways of genes include insulin-like growth factor I binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic.