Identification of Susceptibility Loci and Genes for Colorectal Cancer ...

(PDF) Identification of susceptibility loci for colorectal cancer in a ...

To identify common variants influencing colorectal cancer (CRC) risk, we performed a meta-analysis of five genome-wide association studies, ...

Colorectal cancer susceptibility loci as predictive markers of rectal ...

Many genome-wide association studies (GWAS) have successfully identified more than 20 SNPs associated with the risk for the development of CRC.8 ...

Identification of genetic susceptibility loci for colorectal tumors in a ...

Genetic Susceptibility Loci · Colorectal Tumor · Genome-wide Meta-analysis · Odds Ratio · Risk Allele · Cyclin D2 (CCND2) · Laminin · Polymorphism ...

Multi-omics analysis to identify susceptibility genes for colorectal ...

Abstract Most genetic variants for colorectal cancer (CRC) identified in genome-wide association studies (GWAS) are located in intergenic regions, ...

Gene–Environment Interaction Involving Recently Identified ...

Gene–Environment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci ; Views Icon Views. Article contents ; Share Icon Share. Facebook ...

Results from the Colon Neoplasia Sibling Study - Cell Press

Only a minority (∼5%) of familial CRC can be explained by known genetic variants. To identify susceptibility genes for familial colorectal ...

Association analyses identify 31 new risk loci for colorectal cancer ...

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide ...

Distinct high resolution genome profiles of early onset and late onset ...

Our aim was to identify differences in the tumor genomes between these groups and pinpoint potential susceptibility loci. Integration analysis ...

(PDF) Identification of specific susceptibility loci for the early-onset ...

Although genome-wide association studies (GWAS) have identified more than 100 colorectal cancer risk loci, most of the biological mechanisms associated with ...

Meta-analysis of genome-wide association data identifies four new ...

A genome-wide association study identifies colorectal cancer susceptibility loci ... analysis to identify each of the ten colorectal cancer susceptibility ...

Targeted sequencing of 36 known or putative colorectal cancer ...

Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes. ; Authors DeRycke MS, Gunawardena S, Balcom JR, et al.

Genome-wide association study identifies two new susceptibility loci ...

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nature genetics. 2008; 40:1426–1435 ...

Identification of potential functional variants and genes at 18q21.1 ...

Genome-wide association studies (GWAS) have identified more than 160 susceptibility loci for colorectal cancer (CRC). The effects of these ...

Identification of a shared protective genetic susceptibility locus for ...

Risk of both colorectal cancer (CRC) and gastric cancer (GC) is considered to be heritable with mounting evidence for their genetic ...

Colorectal cancer susceptibility loci and influence on survival

Genome-wide association studies (GWAS) have identified multiple single-nucleotide polymorphisms (SNPs) associated with colorectal cancer ...

Characterization of Gene–Environment Interactions for Colorectal ...

Recent work postulates that there may be up to 65 to 70 common loci underlying CRC susceptibility, requiring large sample sizes for detection (11); additional ...

Identification of a functional variant for colorectal cancer risk ...

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.

Architecture of Inherited Susceptibility to Colorectal Cancer - MDPI

Genetic linkage and positional cloning studies identified the first high-penetrance genes for CRC in the 1980s and 1990s. More recent genome- ...

Evaluation of gene-environment interactions for colorectal cancer ...

Genome-wide association studies (GWAS) have identified more than 40 colorectal cancer susceptibility loci, but only a small fraction of ...

Fine-mapping of colorectal cancer susceptibility loci at 8q23.3 ...

We have previously identified several colorectal cancer (CRC)-associated polymorphisms using genome-wide association (GWA) analysis. We sought to fine-map ...