Identification of Therapy|Induced Clonal Evolution and Resistance ...

Clonal Evolution in Cancer - Mission Bio

The introduction of an anti-cancer treatment into the tumor environment, for example, can dramatically remodel tumors by killing some cells and enabling the ...

Identification of therapy-induced clonal evolution and resistance ...

Identification of therapy-induced clonal evolution and resistance pathways in minimal residual clones in multiple myeloma through single-cell sequencing. Cui, ...

Clonal evolution leading to ibrutinib resistance in chronic ...

Regression models were used to identify factors associated with progression. Time to progression (TTP) was defined from the start of ibrutinib until disease ...

Identification of Therapy-Induced Clonal Evolution and ... - Altmetric

Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing.

Study Identifies Factors in Clonal Evolution of Chemotherapy ...

Gene set enrichment analysis identified clonal enrichment of mutations in pathways involved in transmembrane transport of small molecules (odds ...

Clonal evolution in hematological malignancies and therapeutic ...

They also suggest that while clonal evolution may contribute to resistance to therapy, treatment may also hasten the evolutionary process. New insights into ...

Genomic and epigenomic evolution of acquired resistance to ...

Heterogeneity of clonal evolutions under combined therapies. Phylogenetic trees show the evolution of clone or subclone at the left side of each ...

Longitudinal Molecular Analysis of Tumor Exome and Transcriptome ...

Beyond the immediate therapeutic implications, this analysis provides additional insights into the clonal evolution of thymic epithelial tumors.

Single-cell DNA-seq depicts clonal evolution of multiple driver ...

As clinical observations have demonstrated the benefit of adapting the targeted therapy to acquired alterations at resistance, a clear ...

Adapting Clinical Paradigms to the Challenges of Cancer Clonal ...

Emerging evidence suggests that cancer branched evolution may affect biomarker validation, clinical outcome, and emergence of drug resistance.

Clinical trial designs for evaluating and exploiting cancer evolution

Other methods of treating resistant clones identified over time ... Exploiting evolution to treat drug resistance: Combination therapy and ...

Clonal evolution of colorectal cancer in a patient with serially ...

Metastatic colorectal cancer represents a striking example of clonal heterogeneity and tumour evolution, which generates acquired resistance to therapy.

Chemoresistance Evolution in Triple-Negative Breast Cancer ...

In the clonal extinction patients, NAC eliminated the tumor cells, leaving only normal diploid cell types after treatment, including many ...

Clonal transcriptomics identifies mechanisms of chemoresistance ...

Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages.

Identification of collateral sensitivity and evolutionary landscape of ...

Conclusion: The use of barcoding technology reveals the clonal dynamics of chemotherapy-induced drug resistance not only from harvested cell ...

Unravelling the Complexity of Colorectal Cancer: Heterogeneity ...

Therapeutic possibilities after detection of resistant clones in ctDNA in the targeted treatment of mCRC. 4.2.2. Clonal Evolution in KRASG12C Mutant mCRC ...

Preventing clonal evolutionary processes in cancer - PNAS

In this context, clonal evolution plays an important role determining tumor responses to treatment. Recent treatment approaches involve the specific targeting ...

Harnessing Tumor Evolution to Circumvent Resistance

Treatment targeting subclonal driver mutations has been associated with resistance and recurrence in chronic myeloid leukemia [19] and multiple myeloma [20].

CLL clonal evolution and the development of therapy ... - Grantome

Through integrated whole-exome and RNA-sequencing of these cohorts, we will characterize the extent of clonal evolution following exposure to these agents, and ...

Tracking clonal evolution of drug resistance in ovarian cancer ...

Using a population genetics Wright-Fisher model, we found evolutionary trajectories of these features were consistent with drug-induced positive ...