Induction of IL|9 in Peripheral Lymphocytes of Rheumatoid Arthritis ...

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis ...

Furthermore, anti-TNFα treatment led to a significant rise in the number of peripheral blood regulatory T cells in RA patients responding to this treatment, ...

Decreased CD4+ Lymphocyte Activation and Increased Interleukin ...

We investigated the effects of acute starvation on mitogen-induced T-cell activation and Th1/Th2 cytokine responses in rheumatoid arthritis (RA) patients.

TNF-α blockade induces IL-10 expression in human CD4+ T cells

We have previously shown that patients with rheumatoid arthritis (RA) have an increased percentage of IL-17+IFN-γ- CD4+ T cells in their ...

T cell homeostasis in patients with rheumatoid arthritis - PNAS

Peripheral blood mononuclear cells (PBMC) were obtained from 51 patients who fulfilled the 1987 American College of Rheumatology criteria for the diagnosis of ...

Diminished cytokine-induced Jak/STAT signaling is associated with ...

We also found that high RA disease activity, compared to low disease activity, was associated with decreased (e.g., IFNα→p-STAT5, IL-10→p-STAT1) ...

Expression and clinical significance of the m6A reader YTHDF2 in ...

Healthy control (HC), Peripheral blood mononuclear cells (PBMC), Rheumatoid arthritis (RA), YT521-B homology domains family 2 (YTHDF2). Display ...

The Search for the Pathogenic T Cells in the Joint of Rheumatoid ...

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. ... peripheral T helper cell subset drives B cells in ...

Altered Memory T Cell Differentiation in Patients with Early ...

The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate ...

NLRP3 inflammasome in rheumatoid arthritis pathophysiology | ITT

Although an anti-inflammatory effect has been reported in the CIA model, where addition of apoptotic cells reduced the arthritis score in a DNA ...

Peripheral blood T lymphocytes from patients with early rheumatoid ...

In addition, surface interleukin-15 (IL-15) was detected on freshly isolated T cells and monocytes from the PB of patients with early RA and the ...

Pro-inflammatory cytokine blockade attenuates myeloid expansion ...

In addition, anakinra reduced expression of inflammation-driven myeloid lineage and proliferation arrest gene programs in HSC of arthritic mice.

6 receptor gp130 is driven by STAT3/IL-7–dependent homeostatic ...

Thus, our results show that autoimmune disease in gp130 mutant mice is caused by increased homeostatic proliferation of CD4+ T cells, which is due to elevated ...

Dysregulated lymphocyte proliferation and differentiation in patients ...

In this paper we confirm that lymphocytes proliferate abnormally in RA patients. This contributes to reduced TRECs in peripheral blood and gives ...

Reduction of peripheral blood T cells producing IFN-γ and IL-17 ...

Abatacept (ABA), a molecule used in the treatment of rheumatoid arthritis (RA), competes with the engagement of. CD28, a T-cell receptor for co-stimulatory ...

Changes in peripheral CD19+Foxp3+ and CD19+TGFβ+ regulatory ...

The mechanistic role of Bregs in autoimmune disease remained unclear. Madan et al. confirmed that the immunomodulation imparted by Bregs was induced by IL-10 ( ...

Physiology and Pathology of Autoimmune Diseases: Role of CD4+ T ...

Methotrexate, a first-line conventional therapeutic agent in RA, attenuates IL-17 production by peripheral blood mononuclear cells in vitro [71] ...

The Proportion of Regulatory T Cells in Patients with Rheumatoid ...

Dysfunction of Tregs is considered to be a pivotal cause of autoimmune diseases, including rheumatoid arthritis (RA). However, previous reports describing the ...

Proportions of cytokine-, IL-9R-, Ki67- or CCR6+ T cells before (pre)...

IL-9-producing Th9 cells display a group of helper T cells with similarities to Th17 and Th2 T cells and have been shown to be involved in synovial inflammation ...

T lymphocytes in the synovial fluid of patients with active rheumatoid ...

immune responses (9), resulting in the induction of IL-4 production by naive T cells and their development into effec- tor cells producing higher levels of this.

T cell - Wikipedia

T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response.