Investigating the Effects of Brain Cholesterol Metabolism Using ...

Cholesterol metabolism and homeostasis in the brain | Protein & Cell

The majority of brain cholesterol accumulates between the perinatal period and adolescence when neurons are encircled by myelin. This de novo synthesis is ...

Brain cholesterol metabolism and Parkinson's disease — Penn State

Conclusions: Results indicate that plasma (S)24-OH-cholesterol (possibly reflecting brain cholesterol metabolism) is inversely linked to PD, is relatively ...

Brain-Derived Neurotrophic Factor Regulates Cholesterol ...

Here we investigate the effect of BDNF on cholesterol biosynthesis in cultured cortical and hippocampal neurons. The results suggest that BDNF ...

CYP46A1 variants influence Alzheimer's disease risk and brain ...

CYP46 is a key protein in brain cholesterol metabolism and might be a genetic risk factor of AD. Our screening of the exonic regions and ...

Cholesterol: Its Regulation and Role in Central Nervous System ...

However, recent results indicate that both cholesterol synthesis and degradation are active in the adult brain as well and that alteration in ...

[PDF] Brain Cholesterol Metabolism and Its Defects - Semantic Scholar

An overview of cholesterol turnover under physiological and pathological conditions is presented (Huntington's, Niemann-Pick type C diseases, ...

A Crosstalk Between Brain Cholesterol Oxidation and Glucose ...

Recently, a molecular link was demonstrated between cholesterol oxidative metabolism and glucose uptake in the brain. In particular, 27-hydroxycholesterol, a ...

Brain cell type-specific cholesterol metabolism and implications for ...

Cholesterol metabolism in both neurons and glial cells contributes to learning and memory. Astrocytes not only provide metabolic substances to ...

Cholesterol metabolism in the brain - ResearchGate

From 0.02% (human) to 0.4% (mouse) of the cholesterol in these pools turns over each day so that the absolute flux of sterol across the brain is ...

Regulation of Brain Cholesterol: What Role Do Liver X Receptors ...

This paper proposes to focus on recent advances in the knowledge of the LXRs roles on brain cholesterol and oxysterol homeostasis, neuroinflammation, ...

Brain Cholesterol Metabolism and Its Defects: Linkage to ...

Many neurodegenerative diseases are characterized by impaired cholesterol turnover in the brain. However, at which stage the cholesterol ...

Thematic review series: Brain Lipids. Cholesterol metabolism in the ...

Thus, although the concentration of cholesterol in the brain of the sheep is ∼12 mg/g at birth, it is only 3.5 mg/g in mice and hamsters. This ...

Cholesterol imbalance linked to neurodegeneration, study suggests ...

Research highlights how cholesterol imbalances in the brain ... synthesis (in the glia and neurons). As humans age, the efficiency of their ...

Assessment of cholesterol homeostasis in the living human brain

No methods are currently available for visualizing cholesterol metabolism in the living human brain; therefore, a noninvasive technology that ...

A computational approach implicates cholesterol metabolism in ...

A computational approach implicates cholesterol metabolism in human brain evolution ... Development (2024) 151 (16): e151_e1601. ... The size of the ...

Brain cholesterol in normal and pathological aging | OCL

Stimulation of the LXR-pathway, that plays a key role in the regulation of cholesterol metabolism in the body and the brain results in an enhanced cholesterol ...

Cholesterol Level and Statin Use in Alzheimer Disease

Statin dosage and brain penetration were alluded to by Meske et al as potential confounding factors in various epidemiological studies; that is, negative ...

PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces ...

Moreover, we investigated PCSK9 neurotoxic effects. In human astrocytoma cells, PCSK9 reduced cholesterol content (−20%; p < 0.05), with a greater effect in ...

Clinicians, Researchers Probe Link Between Cholesterol Synthesis ...

For the past three years, researchers at Penn State Cancer Institute have continued their investigation into the effects of statins in the treatment of cancer, ...

Distinct effects of cholesterol profile components on amyloid and ...

Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with ...