Ligand|Independent Epidermal Growth Factor Receptor ...

Epidermal Growth Factor Receptor Cell Proliferation Signaling ...

Here, we review the molecular mechanisms that regulate EGFR signal transduction, including the EGFR structure and its mutations, ligand binding and EGFR ...

EGFR - Epidermal growth factor receptor - Homo sapiens (Human)

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular ...

EGF (Epidermal Growth Factor) Receptor Ligands in Atrial Fibrillation

EGF (Epidermal Growth Factor) Receptor Ligands in Atrial Fibrillation: From Genomic Evidence to the Identification of New Players

Two independent variants of epidermal growth factor receptor ...

Discussion. This study suggests that specific loci in EGFR are associated with an increased risk of glioma. Moreover, two independent coding ...

QuickGO::Term GO:0007173

The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell.

Connective tissue growth factor is a new ligand of epidermal growth ...

EGFR kinase inhibition decreased CCN2(IV)-induced renal changes (ERK activation and inflammation). Studies in cultured tubular epithelial cells ...

The Epidermal Growth Factor Receptor Pathway: A Model for ...

EGFR becomes activated by receptor overexpression (frequent in cancer) as well as ligand-dependent and ligand-independent mechanisms. There are ...

Structural basis for inhibition of the epidermal growth factor receptor ...

By contrast with trastuzumab, which does not prevent ligand-induced ErbB receptor activation, the primary mechanism of cetuximab is to block ligand-stimulated ...

Metalloprotease-mediated ligand release regulates autocrine ...

Ligands that activate the epidermal growth factor receptor (EGFR) are synthesized as membrane-anchored precursors that appear to be proteolytically released ...

Low-affinity ligands of the epidermal growth factor receptor are long ...

We show that EREG, a low-affinity EGFRL, exhibits the most rapid and efficient activation of EGFR in confluent epithelial cells and mouse epidermis.

Immunodetection of the Ligand-Activated Receptor for Epidermal ...

... Epidermal Growth Factor receptor (EGFr) with a monoclonal antibody (mAb74). This antibody was found to preferentially recognize the ligand-activated EGFr as ...

Autocrine expression of the epidermal growth factor receptor ligand ...

We propose an autocrine EGFR stimulation model in cervical carcinoma, with cervical cancer cells being the predominant source of HB-EGF.

Induction of the epidermal growth factor receptor and its ligands in ...

We tested the hypothesis that nasal epithelial cells respond to ozone-induced oxidant stress by modulating expression of the EGFR and its ligands, EGF and ...

Single molecular dissection of the ligand binding property of ...

In this study, the binding abilities of EGF and TGF-α to EGFR on human bladder cancer (T24) cells were investigated by single molecular force spectroscopy (SMFS) ...

Programmed death-ligand 1 expression according to epidermal ...

NSCLC, non-small cell lung cancer; ALK, anaplastic lymphoma kinase; EGFR, epidermal growth factor receptor. Characteristics of final 77 patients ...

5WB7: Crystal structure of the epidermal growth factor receptor ...

We show how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region.

Ligands of Epidermal Growth Factor Receptor and the Insulin-Like ...

Results. The effect of EGFR-TKIs treatment on DSS showed a significant difference by TGFa and ARG (interaction p = 0.046 and p = 0.004, respectively). Low ...

Trafficking of Epidermal Growth Factor Receptor Ligands in ...

A largely unilamellar epithelial layer lines body cavities and organ ducts such as the digestive tract and kidney tubules.

Direct Interaction of a Ligand for the erbB2 Oncogene ... - Science

... epidermal growth factor receptor (EGFR). A 30-kilodalton factor (gp30) secreted from MDA-MB-231 human breast cancer cells was shown to be a ligand for p185erbB2 ...

like repeats of human tenascin-C as ligands for EGF receptor

Herein, we describe a new class of ligand for the epidermal growth factor (EGF) receptor (EGFR) found within the EGF-like repeats of tenascin-C, an antiadhesive ...