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Low dose cisplatin weekly versus high dose cisplatin every ...


Low dose cisplatin weekly versus high dose cisplatin every ... - PLOS

A cumulative cisplatin dose of 200 mg/m2 or more is war- ranted for better survival and locoregional control. Patients with a low skeletal ...

Low dose cisplatin weekly versus high dose cisplatin every three ...

Chemoradiotherapy with cisplatin in a triweekly regimen of 100 mg/m2 body surface area, is used to treat locally advanced head and neck squamous cell carcinoma ...

Low-Dose Weekly vs High-Dose Cisplatin - ClinicalTrials.Veeva

The risk of hearing loss was reduced with cisplatin administered on a weekly low dose (LD) compared to a HD schedule. PFS and OS were similar ...

Weekly Low-Dose Versus Three-Weekly High-Dose Cisplatin for ...

It is suggested that low-dose weekly cisplatin should not be used outside clinical trials but first prospectively studied in adequately sized phase III ...

Comparing High-Dose Cisplatin Every Three Weeks to Low-Dose ...

This study is being done to find out if low-dose cisplatin given weekly together with radiation therapy is the same or better than high-dose ...

comparison of low-dose daily cisplatin

Renal and hematologic parameters were assessed every week. Daily chemotherapy was given on an outpatient basis. Arm 2-weekly cisplatin 40 mg/m2. Inj ...

Study supports weekly low-dose cisplatin for advanced head and ...

... dose cisplatin with concurrent radiotherapy achieved the same survival as those who received standard high-dose cisplatin every 3 weeks plus ...

Treatment outcomes of standard (high dose) cisplatin and non ...

Based on these trials, the addition of cisplatin at 100 mg/m2 (HD-cisplatin) administered once every 3 weeks concurrently with RT was ...

Low dose cisplatin weekly versus high ... - Onderzoek met mensen

CDLT is defined as any toxicity resulting in a cisplatin dose-reduction of. >=50%, a postponement of treatment of >=4 days or a definite ...

Concurrent Chemoradiation with Low-Dose Weekly Cisplatin in ...

Locally advanced head and neck squamous cell carcinoma (HNSCC) is currently treated with concurrent chemoradiation (CRT) or surgery followed by ...

High-dose versus low-dose cisplatin with definitive concurrent ...

Background: Radiotherapy (RT) with concurrent high-dose cisplatin (HDC) improves outcomes for patients (pts) with SCC. Weekly low-dose cisplatin (LDC) is a ...

Standard versus fractionated high-dose cisplatin plus radiation for ...

Chemoradiotherapy with high-dose cisplatin (HD-Cis: 100 mg/m2 q3w for three cycles) is the standard of care (SOC) in locally advanced head and neck squamous ...

Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin ...

This study is being done to answer the following questions: 1. Does low-dose cisplatin given weekly with radiation have fewer side effects than high-dose ...

Low dose cisplatin weekly versus high dose cisplatin every three ...

Cisplatin dose limiting toxicity (CDLT) occurs often and impedes obtaining the planned cumulative cisplatin dose. A cumulative cisplatin dose of 200 mg/m2 ...

Long-Term Update of a Phase 3 Randomized Study Comparing ...

In the weekly-3-weekly study, cisplatin at 100 mg/m 2 once-every-3-weeks led to superior locoregional control compared with cisplatin 30 mg/m 2 once-a-week.

and nephrotoxicity profile of weekly versus every 3-weekly cisplatin ...

Cisplatin is a frontline anticancer drug routinely used as part of concurrent chemoradiation administered at 3-weekly (100 mg/m2) dose.

A comparative study between cisplatin weekly versus every 3 | 96415

Conclusion: High dose cisplatin concomitantly used with radiotherapy showed higher but insignificant survival in comparison with low dose cisplatin with better ...

NCT05050162 – NRG-HN009: Randomized Phase II/III Trial of ...

This study is being done to find out if low-dose cisplatin given weekly together with radiation therapy is the same or better than high-dose ...

292-Head and neck SCC locally advanced definitive ciSplatin ... - eviQ

Low-dose weekly cisplatin seems to have modest tumor radiosensitization but can increase the risk of late swallowing complications. ... Sautois, B., H. Schroeder, ...

Weekly Cisplatin and Radiotherapy - SWAG Cancer Alliance

Renal impairment. CrCl (mL/min). Cisplatin Dose. ≥60. 100%. 50-59. Discuss with ... Phenytoin: reduced serum levels of phenytoin (due to reduced absorption and/or ...