Mechanisms for size|dependent protein segregation at immune ...

Higher-order assemblies in immune signaling - Oxford Academic

First, through stable protein-protein interactions, proteins may form supramolecular complexes with solid-like behaviors and defined shapes. These ...

Boltzmann energy-based image analysis demonstrates that ... - Ebsco

... protein size. Simulations of this mechanism ... dependent exclusion, and further ... size differences explain protein segregation at immune synapses.

The interplay between membrane topology and mechanical forces ...

Many proteins possessing large glycosylated extracellular domains, the glycocalyx, insulate T cells from other cells and can be thought of ...

Crosstalk between protein post-translational modifications and ...

Site-specific protein modifications regulate the onset of phase separation, and notably other point mutations do not affect droplet formation, a ...

Low membrane fluidity triggers lipid phase separation and protein ...

... dependent liquid‐ordered phase that forms nanodomains (lipid rafts) ... segregation and compaction mechanisms (Fig 4A and Appendix Fig S4A).

Partitioning to ordered membrane domains regulates the kinetics of ...

The mechanisms and determinants of secretory and membrane protein sorting ... proteins positively regulating the activation of lymphocytesImmune ...

Phosphatidylserine translocation at the yeast trans-Golgi network ...

Lipid-dependent protein sorting (“lipid raft”–based sorting) has ... Structural mechanism for sterol sensing and transport by OSBP-related ...

Size-dependent protein segregation at membrane interfaces - ORA

Membrane interfaces formed at cell-cell junctions are associated with characteristic patterns of membrane protein organization, such as E-cadherin ...

Knocking 'em Dead: Pore-Forming Proteins in Immune Defense

understood mechanisms that may or may not involve transmembrane pores (7–14). ... (MACPF)/cholesterol-dependent cytolysin (CDC) protein superfamily, which ...

Death domain fold proteins in immune signaling and transcriptional ...

Studies of immune signaling components have revealed that DDF-mediated filament formation plays a central role in mediating signal transduction ...

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

ALIX, together with ESCRT proteins, also plays a role in exosome biogenesis (Abrami et al., 2013; Baietti et al., 2012), consistent with the ...

Phase separation in immune regulation and immune-related diseases

Unlike protein aggregation where substrates lose biochemical activity due to misfolding or loss of mobility, phase-separated substrates often ...

ER-phagy: mechanisms, regulation, and diseases connected to the ...

Moreover, selective clearance of ER subdomains participates in the control of ER size and activity during ER stress, the reestablishment of ER homeostasis after ...

Asymmetric Proteasome Segregation as a Mechanism for Unequal ...

Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed ...

Mechanism of cargo sorting into small extracellular vesicles

The endosomal sorting complex required for transport (ESCRT) is the most known ubiquitin-dependent mechanism responsible for sorting ubiquitinylated proteins ...

Understanding exocytosis in immune and inflammatory cells

26. Rothman, JE. Mechanisms of intracellular protein transport. Nature. 1994 ... dependent mechanism: effects on GTP/GDP binding and cellular distribution.

Mechanisms of lysosomal tubulation and sorting driven by LRRK2

J.G.. et al. (. 2000. ) Kinesin-dependent axonal transport is mediated by the Sunday driver (SYD) protein . Cell. 103. ,. 583. –. 594. https:// ...

Size-dependent activation of CAR-T cells | Science Immunology

However, the rational selection of antigens and the design of CARs are limited by a lack of knowledge on the molecular mechanism underlying ...

A Novel Size-Based Sorting Mechanism of Pinocytic Luminal ...

However, how microglia process the endocytosed contents and evoke an immune response remain unclear. Here we report that a size-dependent ...

Protein - Wikipedia

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions ...