Mechanisms of NLRP3 inflammasome activation and the ...

Mechanisms of inflammasome activation and regulation | Journal of ...

It was hypothesized that this cell cycle–mediated restriction of NLRP3 activation is caused by the limited cellular concentration of NEK7, such ...

The NLRP3 inflammasome: contributions to inflammation-related ...

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and ...

[PDF] The NLRP3 Inflammasome: An Overview of Mechanisms of ...

Current understanding of the mechanisms ofNLRP3 inflammasome activation by multiple signaling events, and its regulation by post-translational modifications ...

Mechanisms of NLRP3 inflammasome activation. The activation of ...

The activation of NLRP3 inflammasome is potentially negatively regulated by small molecules, such as COPs and POPs, cells and cytokines, autophagy, NO, and CO.

Research progress on the activation mechanism of NLRP3 ...

The NLR inflammasome is a polyprotein oligomer composed of upstream sensor proteins (Nod-like receptors), adaptor proteins, apoptosis-related ...

NLRP3 Inflammasome Priming and Activation Are Regulated by a ...

The activation of NLRP3 inflammasome involves two steps in which NLRP3 is first licensed downstream of TLR signaling. This step, also known as the priming step, ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

inflammasome activation will boost the development of its specific inhibitors to treat NLRP3-related diseases. Open questions. What factors ...

Structural basis for the oligomerization-mediated regulation ... - PNAS

A multilayered regulatory mechanism ensures proper NLRP3 inflammasome activation, although the structural basis for this process remains unclear ...

Inflammasomes: Mechanisms of Action and Involvement in Human ...

NLRP3 inflammasome activation is likely regulated by various post-translational modifications, with ubiquitination and phosphorylation being the most thoroughly ...

Formation of the NLRP3 inflammasome inhibits stress granule ...

We also found that a decrease in intracellular potassium (K+) concentration, a key 'common' step in NLRP3 inflammasome activation, markedly inhibited SG ...

NLRP3 inflammasome activation, metabolic danger signals, and ...

The NLRP3 inflammasome can be activated through several principal mechanisms, including K + efflux, lysosomal damage, and the production of mitochondrial ...

Molecular regulation of NLRP3 inflammasome activation during ...

NLRP3 inflammasome is a critical part of innate immune response and its activation is an important antimalarial mechanism. During infection NLRP3 inflammasome ...

Mechanism of NLRP3 inflammasome activation. - Abstract

This potent caspase-1-dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

Discover this 2019 paper in Cell death & disease by Yang, Yang; Wang, Huanan; Kouadir, Mohammed; et. al. Abstract: The NLRP3 inflammasome is a multimeric ...

NLRP3 Inflammasome Activation - Promega Corporation

The NLRP3 inflammasome detects stress signals, like extracellular ATP released by damaged cells. These signals activate the inflammasome and recruit caspase-1 ...

The NLRP3 Inflammasome: An Overview of Mechanisms of ...

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines ...

Predicting Multi-Interfacial Binding Mechanisms of NLRP3 and ASC ...

NLRP3-PYD inflammasome activates an inflammatory pathway in response to a wide variety of cell damage or infections. Dysregulated NLRP3 ...

SLC25A3 negatively regulates NLRP3 inflammasome activation by ...

The NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome activation plays a critical role in innate ...

Role of the NLRP3 inflammasome in cancer

The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving ...