Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell ...

Metabolic remodeling during the loss and acquisition of pluripotency

Among the various cell types known in animals, only pluripotent stem cells have the capacity to self-renew indefinitely, while still retaining ...

Metabolism in pluripotency: Both driver and passenger?

Metabolic regulation in pluripotent stem cells during reprogramming and ... abolic shift during induced pluripotent stem cell reprogramming.

Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell ...

However, induced pluripotent stem cells (iPSC) retain transcriptional memory, epigenetic memory, and metabolic memory from their somatic cells of origin and ...

Metabolic Regulation of Stem Cells and Differentiation: A Forkhead ...

FOXOs are multitasking proteins as they are key regulators of the cell cycle, metabolism, and the oxidative stress response (reviewed in Liang and Ghaffari 99).

Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell ...

Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming. ... However, induced pluripotent stem cells (iPSC) retain ...

Energy Metabolism in Human Pluripotent Stem Cells and ... - PLOS

ATP levels, lactate production and OCR revealed that human pluripotent cells rely mostly on glycolysis to meet their energy demands.

Metabolic regulation in pluripotent stem cells | Request PDF

Finally, metabolism is not simply regulated by exogenous stimuli or nutrient availability in PSCs, as key pluripotency regulators, such as Oct4, ...

from embryonic development to stem cell differentiation - Browse ...

Metabolism is central to pluripotency and differentiation, with lasting impacts on derived cell identity through regulation of the epigenetic ...

O-GlcNAcylation regulates the methionine cycle to promote ... - PNAS

Methionine metabolism is critical for the maintenance of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) pluripotency. However, little is ...

Stem Cell Metabolism: Powering Cell-Based Therapeutics - MDPI

Somatic cell reprogramming to induced pluripotent stem cell (iPSC) involves a metabolic shift from OxPhos to glycolysis. The early expression of ERRα, ERRβ, and ...

Metabolism of human pluripotent stem cells and differentiated cells ...

Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling.

Metabolic control of primed human pluripotent stem cell fate and ...

Taken together, our results identify the miR-200c-SIRT2 axis as a key regulator of metabolic reprogramming (Warburg-like effect), via regulation of glycolytic ...

Metabolic remodeling during somatic cell reprogramming to induced ...

Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, ...

"Whence Cometh Cell Fate?" Metabolism as the New Frontier in ...

... induced pluripotent stem cells (iPSCs), all driven by pioneering transcription factors. ... key regulator of myogenic potency in muscle stem cells. We found that ...

15 - The metabolic framework of pluripotent stem cells and potential ...

Induced pluripotent stem (iPS) cells promise enormous potential for the generation of cells for regenerative medicine, drug discovery, and understanding disease ...

piRNAs are regulators of metabolic reprogramming in stem cells

Conversely, oxidative metabolism is activated during the differentiation of pluripotent stem cells, and differentiation can be suppressed ...

UCLA stem cell researchers uncover mechanism that regulates ...

Human pluripotent stem cells, which can develop into any cell type in the body, rely heavily on glycolysis, or sugar fermentation, ...

Unveiling dynamic metabolic signatures in human induced ... - PLOS

We applied principles of process dynamics and control to human induced pluripotent stem cells (hiPSC) and human neural stem cells (hNSC) ...

Isotopic Tracing of Nucleotide Sugar Metabolism in Human ...

Metabolism not only produces energy necessary for the cell but is also a key regulator of several cellular functions, including pluripotency ...

a key regulator of hematopoietic stem cell fate in health and disease ...

Abstract. Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute need.