- Breast Cancer Risk Is Associated with the Genes Encoding the DNA ...🔍
- High Expression of MRE11–RAD50–NBS1 Is Associated with Poor ...🔍
- Regulation of Mre11/Rad50 by Nbs1🔍
- The MRN complex🔍
- The Mre11|Rad50|Nbs1 Complex Mediates Activation of TopBP1 by ...🔍
- Enhanced phosphorylation of Nbs1🔍
- Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 ...🔍
- Mre11–Rad50🔍
Modification in the Expression of MRE11/RAD50/NBS1 Complex in ...
Breast Cancer Risk Is Associated with the Genes Encoding the DNA ...
Abstract. The evolutionarily conserved Mre11-Rad50-Nbs1 (MRN) complex, consisting of proteins encoded by the genes Mre11, Rad50, and Nbs1, was recently.
High Expression of MRE11–RAD50–NBS1 Is Associated with Poor ...
Background: The MRN complex of meiotic recombination 11 (MRE11), DNA repair protein Rad50 (RAD50) and Nijmegen breakage syndrome 1 (NBS1) proteins ...
Regulation of Mre11/Rad50 by Nbs1 - Journal of Biological Chemistry
In mammalian cells, Mre11/Rad50 (M/R) associates with a third component, Nbs1, that regulates its activities and is targeted by signaling pathways that initiate ...
The MRN complex: coordinating and mediating the response to ...
The MRE11–RAD50–NBS1 (MRN) protein complex has been linked to many DNA metabolic events that involve DNA double‐stranded breaks (DSBs).
The Mre11-Rad50-Nbs1 Complex Mediates Activation of TopBP1 by ...
This interaction involves the Nbs1 subunit of the complex. ATM can no longer interact with TopBP1 in Nbs1-depleted egg extracts, which suggests ...
Enhanced phosphorylation of Nbs1, a member of DNA repair ...
However, MMC treatment did not change the expression of Mre11, RAD50, and Nbs1 proteins (Figure 2A). In addition, other genotoxic agents such as hydroxyurea (HU) ...
Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 ... - PNAS
The Mre11/Rad50/Nbs1 (MRN) complex recognizes double-strand breaks in eukaryotic cells, initiating DNA repair and signaling cell cycle checkpoint arrest.
Mre11–Rad50: the DNA end game | Biochemical Society Transactions
The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of ...
Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair ...
To organize the MRN complex, the Mre11 exonuclease directly binds Nbs1, DNA, and Rad50. Rad50, a structural maintenance of chromosome (SMC) related protein, ...
The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin [1] in humans and as Xrs2 in yeast).
The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double ...
Recent evidence suggests that the DNA repair complex containing Mre11, Rad50 and Nbs1 (MRN) is important for the activation of ATM by. DSBs in cells. Our ...
Adenovirus Regulates Sumoylation of Mre11-Rad50-Nbs1 ...
The Mre11-Rad50-Nbs1 (MRN) complex plays a key role in the DNA damage response, presenting challenges for DNA viruses and retroviruses.
The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair ...
... alterations in pathways downstream of the initial DNA damage can alter ... Suppression of Mre11 protein expression inhibits the ability of U87 cells to ...
The Mre11-Rad50-Nbs1 Complex Acts Both Upstream and ...
The Mre11-Rad50-Nbs1 (MRN) complex is required for mediating the S-phase checkpoint following UV treatment, but the underlying mechanism is not clear.
The involvement of the Mre11/Rad50/Nbs1 complex ... - EMBO Press
To investigate whether the Mre11/Rad50/Nbs1 (MRN) complex is involved in the generation of proper 3′ G‐overhangs at human telomere ends, we used RNA ...
The MRE11-RAD50-NBS1 complex both starts and extends DNA ...
Here we examine roles of the conserved MRN complex (MRE11, RAD50, and NBS1) through genome-wide analysis of meiotic resection in mice with various MRN ...
Post-Translational Modification of MRE11: Its Implication in DDR ...
Maintaining genomic stability is vital for cells as well as individual organisms. The meiotic recombination-related gene MRE11 (meiotic recombination 11) is ...
Resection of DNA double-strand breaks activates Mre11–Rad50 ...
DSBs are primarily detected by the ATM checkpoint pathway, where the Mre11–Rad50–Nbs1 (MRN) complex serves as the DSB sensor. Subsequent DSB end resection ...
In combination with NBS1, MRE11 and RAD50 constitute an MRN (MRE11-RAD50-NBS1) complex that repairs DNA damage. However, certain genetic alterations in MRE11 ...
MiR-140 leads to MRE11 downregulation and ameliorates ...
MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment. Mol Cancer (2019) 18(1):169. doi: 10.1186 ...