Motor stimulant effects of the adenosine A2A receptor antagonist ...

Stimulant effects of adenosine antagonists on operant behavior - Scite

Supporting: 2, Mentioning: 27 - Rationale Adenosine A2A antagonists can reverse many of the behavioral effects of dopamine antagonists, including actions on ...

Adenosine A2A receptor antagonist - Wikipedia

Adenosine A2A receptor antagonists are a class of drugs that blocks adenosine at the adenosine A2A receptor. Notable adenosine A2A receptor antagonists ...

A Crucial Role for Forebrain Adenosine A2A Receptors in ... - OUCI

Halldner L, Lozza G, Lindstrom K, Fredholm BB (2000). Lack of tolerance to motor stimulant effects of a selective adenosine A(2A) receptor antagonist. Eur J ...

Targeting adenosine A2A receptors in Parkinson's disease

Blockade of the adenosine A2A receptor in striatopallidal neurons reduces postsynaptic effects of dopamine depletion, and in turn lessens the motor deficits of ...

A2A adenosine receptor antagonism enhances synaptic and motor ...

... stimulant effects of cocaine. In this study, we analyzed the electrophysiological effects of cocaine and A2A-Rs antagonists in striatal slices and the motor ...

Brain Adenosine A2A Receptor Occupancy by a Novel A1/A2A ...

The antimotor-impairment effect of ASP5854 was induced by a dose of from 0.066 to 1 mg/kg, an ED50 value in various rodent motor-impairment models (13). In the ...

Caffeine and a selective adenosine A2A receptor antagonist induce ...

These data indicate that striatal dopaminergic pathways play an important role in mediating the locomotor sensitization and reward effects after ...

Two new adenosine receptor antagonists for the treatment of ...

loses its motor stimulant properties in the A2A receptor knockout (KO) mouse model [16]. A2A receptors may also form heteromers with glutamatergic. mGlu5 ...

Interactions between Metabotropic Glutamate 5 and Adenosine A2A ...

that relatively mild motor stimulant effect of A2A antagonists in some species may reflect a greater tonic stimulation or basal ac- tivity of the mGlu5 ...

The Pharmacological Potential of Adenosine A2A Receptor ... - MDPI

In contrast, an inverse agonist would remove both the effects of adenosine on the A2A receptor and its constitutive activity, having greater efficacy in ...

Effect of adenosine A receptor antagonists on motor disorders ...

study, acquisition of data. ABSTRACT. PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat.

Effects of an Adenosine A2A Receptor Antagonist on ... - Frontiers

On this basis, A2A receptor antagonism could prevent D2-type receptor internalization and may therefore induce upregulation of these receptors ...

Increased adenosine A2A receptors in the brain of Parkinson's ...

Comparable effects of A2AR antagonists on levodopa‐induced motor complications are found in rats with a unilateral 6‐hydroxydopamine (OHDA)‐induced dopaminergic ...

Adenosine A2A and dopamine D2 receptor interaction controls ...

While systemic DPCPX had little effect on motor performance or fatigue, the application of either caffeine or SCH58261 was ergogenic, and these effects were ...

Cardiovascular and Subjective Effects of the Novel Adenosine A 2A ...

Specifically, A2A receptor antagonists increase the effect of dopamine at these receptors, which are tonically inhibited by endogenous adenosine [7,8,12]. It ...

Caffeinated clues and the promise of adenosine A2A antagonists in ...

This symptomatic antiparkinsonian benefit of blocking A2A receptors, coupled with their remarkably restricted expression in the basal ganglia, have made A2A ...

Involvement of Adenosine A1 and A2A Receptors in the Motor ...

In the present study, counteraction of the motor-depressant effects of the selective A1 receptor agonist CPA and the A2A receptor agonist CGS 21680 by caffeine, ...

Adenosine A2A receptor antagonists are potential antidepressants ...

1. Adenosine, an ubiquitous neuromodulator, and its analogues have been shown to produce 'depressant' effects in animal models believed to be relevant to ...

Istradefylline – a first generation adenosine A 2A antagonist for the ...

In animal models, there is consensus that a more robust effect of istradefylline in improving motor function is produced when combined with low or threshold ...

Uncovering Caffeine's Adenosine A2A Receptor Inverse Agonism in ...

The mechanism by which caffeine contributes to its antiparkinsonian effects by acting as either an adenosine A2A receptor (A2AR) neutral ...