New pathway linking neuron selectivity to cognitive disorders ...

Vascular Contributions to Cognitive Impairment and Dementia | Stroke

The neuropathology of cognitive impairment in later life is often a mixture of Alzheimer disease and microvascular brain damage, which may ...

Exploring the Role of Neuroplasticity in Development, Aging, and ...

Of note, new neurons also need to migrate to their appropriate locations within the brain. This process involves the support of radial glial cells and Cajal– ...

Linking Neuronal Direction Selectivity to Perceptual Decisions About ...

These questions are addressed below. COGNITIVE SIGNALS IN NEURONS REPRESENTING. VISUAL MOTION. Spatial and Feature-Based Attention for Motion.

Amplified selectivity in cognitive processing implements the neural ...

Mather and colleagues' article joins the growing body of work suggesting that norepinephrine, through its brainwide effect on neural gain, selectively enhances ...

Levetiracetam suppresses neuronal network dysfunction and ...

Our findings support the hypothesis that aberrant network activity contributes causally to synaptic and cognitive deficits in hAPP mice.

Different neural pathways linking personality traits and eudaimonic ...

... cognitive impairment: A resting-state fMRI study. NeuroImage, 55(1) ... Linking inter-individual differences in neural activation and behavior to ...

Targeting the molecular web of Alzheimer's disease

Cognitive impairment is more closely associated with a decrease in the density of presynaptic boutons from pyramidal neurons in laminae III and ...

Tau and neuroinflammation in Alzheimer's disease

... linked to cognitive deficits. Accumulating evidence indicates that ... neuronal loss in mild cognitive impairment and alzheimer disease.

Mount Sinai Researchers Uncover a Neural Pathway that is Critical ...

This process, called cognitive control, is frequently dysregulated in a wide range of psychiatric disorders. The team's research, published ...

How the Brain Changes With Age - BrainFacts

Although synaptic changes are selective and subtle, their effect on cognitive decline is believed to be greater than the effects of structural ...

Astrocytic TDP-43 dysregulation impairs memory by modulating ...

... cognitive impairment through ... Similarly, AD-linked tau accumulation in hippocampal astrocytes promotes selective neuronal deficits (96).

Multiple dynamic interactions from basal ganglia direct and indirect ...

Optogenetic inhibition, as well as selective ablation of direct pathway, impairs action selection, and optogenetic excitation of direct pathway ...

Untangling this interconnection might be instrumental in designing novel therapies that can minimize epileptic seizures and cognitive deficits ...

Hub overload and failure as a final common pathway in neurological ...

In stroke, damage to hubs is associated with impaired cognitive recovery. Breakdown of optimal brain network organization in multiple sclerosis ...

A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates ...

Additionally, we found that LC to dCA1 projecting neurons modulate the excitability of dCA1 neurons, and the extent of overlap between dCA1 ...

GABA—from Inhibition to Cognition: Emerging Concepts

At the one end of the spectrum, GABAergic neurons have been accurately described with regard to cell morphological, molecular, and ...

Distribution of analysis windows of stimulus-selective neurons....

... blockade of both NMDA and GABA(A) receptors thus improved working memory selectivity to stimulus condition (Fig. 5). The distribution of analysis window ...

Nervous System News - ScienceDaily

14, 2024 — Researchers have revealed how two neural circuits located in the brain's retrosplenial cortex are directly linked to spatial navigation and memory ...

An Expanded Narrative Review of Neurotransmitters on Alzheimer's ...

Dopamine (DA) is a monoamine neurotransmitter that has a role in higher function performance of the brain. Basically, it has a neural effect on ...

Activation of autophagy rescues synaptic and cognitive deficits in ...

Autophagy Is Down-Regulated in Hippocampal Neurons of Fragile X Mice. Initiation of macroautophagy starts with autophagosome formation, which depends on the ...