New vascular insights into premature aging

Vascular aging: insights from studies on cellular senescence, stem ...

The cardiovascular research on cellular senescence, stem cell aging, and progeroid syndromes is reviewed and the potential role of cellularsenescence in the ...

Mechanisms of Vascular Aging: New Perspectives - Oxford Academic

Moreover, age-related alterations in cellular homeostatic mechanisms also render the aged vasculature more susceptible to the damaging effects ...

Edward F. Adolph Distinguished Lecture: Skin-deep insights into ...

The skin is an accessible model circulation for studying vascular function and dysfunction across the lifespan. Age-related changes, as well as those ...

New insights into the effect of aging on cardiovascular disease

Aging adults are more likely to have—and die from—cardiovascular disease than their younger counterparts. New basic science research finds ...

Vascular smooth muscle cell aging: Insights from Hutchinson-Gilford ...

Vascular dysfunctions are a common feature of multiple age-related diseases. However, modeling healthy and pathological aging of the human vasculature ...

Premature Aging, Vascular Disease and Endothelial ... - Grantome

Just as monogenic diseases such as familial hypercholesterolemia and familial defective apoB-100 have provided powerful molecular insights into the pathogenesis ...

A key mechanism in the development of cardiovascular disease in ...

People with HGPS show signs of rapid ageing in early life and develop severe atherosclerosis in adolescence, leading to cardiovascular ...

'Paving the way' for improved treatment of premature aging disease

Published in the journal Aging Cell on October 18, 2024, in collaboration with researchers from the National Institutes of Health (NIH) and Duke ...

Impact of Aging on Cardiovascular Diseases: From Chronological ...

Several cardiac and vascular functional or structural parameters are featured in aging studies such as pulse-wave velocity (PWV), arterial ...

New high-resolution 3D maps show how the brain's blood vessels ...

Aged brains show reduced vascular length and branching density, increased radii, reduced pericyte density, leaky blood-brain barrier and lower ...

Uremic Toxins Promote Early Vascular Ageing in CKD

Chronic kidney disease (CKD) is a clinical model of premature ageing, a phenomenon described as a discrepancy between chronological and biological age. One ...

New Insights into the Mechanism of Action of Soluble Klotho - Frontiers

In 1997, one such gene was identified in a transgenic mouse strain whose mutation resulted in a syndrome resembling premature aging that included shortened ...

Study of Aging Pioneered at Cedars-Sinai

An expanding body of preclinical research suggests that mechanisms of aging—inflammation, shifts in immunity and epigenetics, stem cell and ...

The Implications of Aging on Vascular Health - MDPI

We also explore aging-related changes in perivascular adipose tissue deposition, arterial collateralization, and calcification, providing insights into the ...

Vascular smooth muscle cell loss underpins the accelerated ...

Mutations in LMNA have been linked to premature aging disorders, including Hutchinson-Gilford progeria syndrome (HGPS). HGPS is caused by progerin, an aberrant ...

Aging impairs the neurovascular interface in the heart - Science

We report that aging reduces nerve density in the ventricle and dysregulates vascular-derived neuroregulatory genes.

New Insight into the Mechanisms of Ginkgo Biloba Extract in ...

Results: Both arterial stiffening and endothelial dysfunction are critical aging-related vascular phenotypes that result in the progression of cardiovascular ...

How Medial Vascular Calcification Impacts Early Vascular Aging

Pharmacy Times interviewed Peter Stenvinkel, MD, PhD, FASN, full professor and senior lecturer in the Department of Renal Medicine at ...

Novel insights into vascular calcification - Kidney International

The presence and extent of vascular calcification is highly correlated with cardiovascular disease and all-cause mortality and extensive arterial calcification ...

Vascular biology in uremia: insights into novel mechanisms of ...

... early atherosclerosis in ApoE-deficient mice. ... In DBA2 background mice, an inbred strain prone to microsurgery-induced calcification of the heart and tongue.