Not only tumor but also therapy heterogeneity

Currently there is no molecular-based targeted therapy for TNBC, and unfortunately only approximately 20% of these tumors respond well to standard chemotherapy.

Intra-tumor heterogeneity from a cancer stem cell perspective

... to this CSC heterogeneity and the potential implications for cancer therapy ... and block differentiation, but is not sufficient to induce ...

What is Tumor Heterogeneity? - News-Medical

As cancer progresses, the tumor begins to consist of more diverse cells with a range of molecular signatures and variable sensitivity to treatment.

Evolution of phenotypic plasticity leads to tumor heterogeneity with ...

Cancer is a significant global health issue, with treatment challenges arising from intratumor heterogeneity. This heterogeneity stems mainly from somatic ...

Intratumor heterogeneity alters most effective drugs in designed ...

Tumors within each cancer patient have been found to be extensively heterogeneous both spatially across distinct regions and temporally in response to ...

Immunological tumor heterogeneity and diagnostic profiling for ...

Non-clonal heterogeneity can often be determined by histomorphological methods and is also correlated in part with genetics. Type, number, and ...

Tumour heterogeneity - Wikipedia

The heterogeneity of cancer cells introduces significant challenges in designing effective treatment strategies. However, research into understanding and ...

Cancer heterogeneity—a multifaceted view | EMBO reports

This so‐called intra‐tumour heterogeneity poses an important challenge for predicting tumour behaviour and clinical outcome. Differences exist not only within a ...

ES 04.03 Tumor Heterogeneity - Journal of Thoracic Oncology

positive AR to EGFR-TKIs.3 However, resistance also occurs under osi- mertinib therapy and the molecular mechanisms, which are partly.

Tumor Heterogeneity - Division of Regenerative Medicine

A central issue that confounds successful treatment of GBM patients is the heterogeneous nature of this aggressive tumor. As a result, multiple and ...

Cancer Stem Cells & Tumor Heterogeneity

Tumor heterogeneity can occur not only within tumorcells but also with regards to the tumor stroma. We previouslyidentified a role for cancer-associated ...

Textural Parameters of Tumor Heterogeneity in 18F-FDG PET/CT for ...

Tumor heterogeneity was found to be a promising predictive and prognostic factor. We investigated textural parameters for their predictive and prognostic ...

MRI-based Quantification of Intratumoral Heterogeneity for ...

Breast cancer is highly heterogeneous, resulting in different treatment responses to neoadjuvant chemotherapy (NAC) among patients. A ...

Intratumor Heterogeneity and Branched Evolution Revealed by ...

Genetic intratumor heterogeneity has also been shown and can contribute to treatment failure and drug resistance. Intratumor heterogeneity may ...

Cheung Group :: DKTK

Notably, therapeutic resistance is controlled not only by cell-autonomous genetic alterations or epigenetic modifications of tumor cells, but also by tumor ...

Heterogeneity in Lung Cancer | Pathobiology - Karger Publishers

Tumour heterogeneity has an important impact not only on tumour classification but also on defining prognosis and therapy decision. So, it ...

Tumor microenvironment plasticity and heterogeneity (TMHet)

Tumors are not composed only by tumor cells, but also include a complex and heterogeneous tumor microenvironment (TME), where immune cells, ...

Tumor heterogeneity: An overlooked issue in cancer therapeutics

This concept also extends to metastases and to differences between primary and metastatic tumors. Cancer heterogeneity has deep implications for therapy. In ...

Tumor Heterogeneity, Plasticity and Therapy - Molecular Machines

Tumors are intricate ecosystems, not just cancer cells. The interplay between these cells and their microenvironment influences tumor evolution and therapy ...

integrating tissue and circulating tumor DNA (ctDNA) analysis in the ...

During therapy plasma ctDNA was monitored, not only ... Assessing tumor heterogeneity using ctDNA to predict and monitor therapeutic response in metastatic breast ...