Notch1 is a target of miR|34c|5p.

Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung ...

Reck was found to be a key direct target gene of miR-221/222 in NSCLC. Overexpression of miR-221/222 significantly suppressed Reck expression, activated Notch1 ...

(PDF) MicroRNA-34c-3p target inhibiting NOTCH1 suppresses ...

PDF | Background Chemotherapy is the standard treatment for non-small cell lung cancer (NSCLC). However, chemoresistance frequently occurs, making the.

Regulación de Notch1 y Foxp1 por MiR-34ª en Psoriasis Vulgaris

By promoting target mRNA degradation and/or translation inhibition, they negatively regulate gene expression at the post-transcriptional level (). The miRNAs ...

Up-regulation of miR-34c-5p inhibits nasopharyngeal carcinoma ...

... target gene sequence fragments. MiR-34c inhibits Bcl2 by pairing to ... MiR-34c-5p targets NOTCH1. It was found that there were sequence fragments on ...

ARRB1-Promoted NOTCH1 Degradation Is Suppressed by ...

Mechanistically, the oncogenic miRNA (oncomiR) miR-223 targets the 3′-UTR of ARRB1 (BUTR) and inhibits its expression in T-ALL. Furthermore, ...

MicroRNA-582-5p suppresses non-small cell lung cancer ... - PLOS

MiR-582-5p targets NOTCH1 directly. To explore the molecular mechanism of miR-582-5p function in NSCLC cells, we used TargetScan, PicTar, and ...

MicroRNA-34c-3p target inhibiting NOTCH1 suppresses ...

MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer. Lin-zhu Yang, Chang-cheng Lei, […] ...

MicroRNA‐34a Promotes Ischemia‐Induced Cardiomyocytes ...

Its activation can be protective in myocardial apoptosis [17]. TargetScan analysis showed Notch1 to be one of the targets of miR-34a, which was ...

Long non-coding RNA TUG1 knockdown hinders the tumorigenesis ...

... NOTCH1 expression by targeting miR-34a-5p. The ... Bioinformatics analysis suggested that NOTCH1 was a potential target of miR-34a-5p.

Non-coding RNAs Affect Breast Cancer Development Through the ...

proposed that miR-449a targets Notch1 and showed that cell proliferation and migration were facilitated by the upregulation of miR-449a.57 Using direct ...

MiR-139-5p inhibits migration and invasion of colorectal cancer by ...

Then, 5 potential target genes with tumor-promoting function (AMFR, NOTCH1, HNRNPF, TOP1, and LAPTM4B) were selected from the 31 genes and their ...

microRNA-139-5p exerts tumor suppressor function by targeting ...

Oncogene NOTCH1 was revealed to be a putative target of miR-139-5p ... NOTCH1 is a direct target of miR-139-5p in colon cancer. (A) Human ...

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in ...

Mechanistically, miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between ...

miR-139/PDE2A-Notch1 feedback circuit represses stemness of ...

FZD3 and β-catenin, which induced Wnt/β-catenin signaling activation, were identified as targets of miR-139 and mediated the effects of miR-139 on GSCs.

Regulation of Notch1 Signalling by Long Non-Coding RNAs ... - MDPI

NEAT1 affects NOTCH1 signalling by suppressing miR-129-5p, which, as described above, targets NOTCH1 mRNA [126]. 4. Medicinal Perspectives for lncRNAs in Notch1 ...

MiR-34a targeted Notch2 to induce apoptosis of medullary thyroid ...

Both bioinformatics analysis and luciferase reporter gene assay demonstrated Notch1 as potential target of miR-34a. MiR-34a mimic transfection ...

Notch1 in Cancer Therapy: Possible Clinical Implications and ...

(Notch1 ligand) and HEY2 (downstream target of Notch1). 562 ... MicroRNA-34a suppresses breast cancer cell proliferation and invasion by targeting Notch1.

MiR-499b-5p inhibits cervical cancer cell proliferation and induces ...

Notch1 Is the Target Gene of. MiR-499b-5p. The Notch signaling pathways that bound to miR-499b-5p were analyzed to further explore the mechanism of miR-499b-5p ...

The ZEB1/miR‐200 feedback loop controls Notch signalling in ...

We show that miR‐200 members target Notch pathway components, such as Jagged1 (Jag1) and the mastermind‐like coactivators Maml2 and Maml3, thereby mediating ...

Notch1/miR-322 Axis in Stem Cell Mediated Vascular Repair ...

... miR-322 and HIF-1?. We propose to investigate how Notch-1 and the newly identified Notch-1 target miR-322 sustain and potentiate the beneficial effects of ...